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Peptide record

TPDB48060

ACE inhibitor from sake lees ACE inhibitors Antihypertensive standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB48060
ACE inhibitor from sake lees
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB AHTpin
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
FWN
Physicochemical Analysis
C24H27N5O5
ARDCEQGHILKMPSTYV
NFW
465.51
6.02
0
0
2
-0
-2.56
-0.533
0.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
5500
1181.50
1
Residue Composition
number
0
A
0
R
1
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
1
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
3
C24H27N5O5
465.51
6.02
-0
-2.56
-0.533
465.5006
465.2006
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
18.30 µM
ACE inhibitor
ah

Source & Reference

NA
Saito Y., Wanezaki K., Kawato A., Imayasu S.
Structure and activity of angiotensin I converting enzyme inhibitory peptides from sake and sake lees. Biosci.Biotech.Biochem.58(10),1767-1771(1994)
1994
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@]([H])(CC(N)=O)C(O)=O InChI=1S/C24H27N5O5/c25-17(10-14-6-2-1-3-7-14)22(31)28-19(23(32)29-20(24(33)34)12-21(26)30)11-15-13-27-18-9-5-4-8-16(15)18/h1-9,13,17,19-20,27H,10-12,25H2,(H2,26,30)(H,28,31)(H,29,32)(H,33,34)/t17-,19-,20-/m0/s1 InChIKey=NJONQBYLTANINY-IHPCNDPISA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
18.30 µM
ACE inhibitor
ah

Source & Reference

AHTPDB
Saito Y., Wanezaki K., Kawato A., Imayasu S.
Structure and activity of angiotensin I converting enzyme inhibitory peptides from sake and sake lees. Biosci.Biotech.Biochem.58(10),1767-1771(1994)
1994
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@]([H])(CC(N)=O)C(O)=O InChI=1S/C24H27N5O5/c25-17(10-14-6-2-1-3-7-14)22(31)28-19(23(32)29-20(24(33)34)12-21(26)30)11-15-13-27-18-9-5-4-8-16(15)18/h1-9,13,17,19-20,27H,10-12,25H2,(H2,26,30)(H,28,31)(H,29,32)(H,33,34)/t17-,19-,20-/m0/s1 InChIKey=NJONQBYLTANINY-IHPCNDPISA-N
Additional Detail Fields 1 fields
3