Back to search

Peptide record

TPDB48055

ACE inhibitor ACE inhibitors Antihypertensive standard
2 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB48055
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB AHTpin
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
AR
Physicochemical Analysis
C9H19N5O3
NDCEQGHILKMFPSTWYV
AR
245.28
11.05
1
0
1
+1
0.64
-1.350
50.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
1
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
2
C9H19N5O3
245.28
11.05
+1
0.64
-1.350
245.2781
245.1484
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
95.50 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Sentandreu M. A., Toldra F.
Evaluation of ACE inhibitory activity of dipeptides generated by the action of porcine muscle dipeptidyl peptidases. Food Chem., 101, 1629-1633, 2007
2007
Journal

Other

2
BIOPEP-UWM database bioactive peptides SMILES: N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O InChI=1S/C9H19N5O3/c1-5(10)7(15)14-6(8(16)17)3-2-4-13-9(11)12/h5-6H,2-4,10H2,1H3,(H,14,15)(H,16,17)(H4,11,12,13)/t5-,6-/m0/s1 InChIKey=SITWEMZOJNKJCH-WDSKDSINSA-N Salty taste enhancing peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 421).
Evidence 2 Activity

Activity

IC50
Antihypertensive
95.50 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Sentandreu M. A., Toldra F.
Evaluation of ACE inhibitory activity of dipeptides generated by the action of porcine muscle dipeptidyl peptidases. Food Chem., 101, 1629-1633, 2007
2007
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP-UWM database bioactive peptides SMILES: N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O InChI=1S/C9H19N5O3/c1-5(10)7(15)14-6(8(16)17)3-2-4-13-9(11)12/h5-6H,2-4,10H2,1H3,(H,14,15)(H,16,17)(H4,11,12,13)/t5-,6-/m0/s1 InChIKey=SITWEMZOJNKJCH-WDSKDSINSA-N Salty taste enhancing peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 421).
Additional Detail Fields 1 fields
2