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Peptide record

TPDB48054

ACE inhibitor Ala-Ala alanyl-alanine dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) Hypotensive peptide ACE inhibitors Antihypertensive iDPPIV Selfassembly standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB48054
ACE inhibitor Ala-Ala alanyl-alanine dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) Hypotensive peptide
ACE inhibitors Antihypertensive iDPPIV Selfassembly
Cardiometabolic peptides Self-assembling and biomaterial peptides
Peptipedia AHTPDB AHTpin iDPPIV SAPdb
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, iDPPIV, and other sources) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
AA
Physicochemical Analysis
C6H12N2O3
RNDCEQGHILKMFPSTWYV
A
160.17
6.02
0
0
2
-0
-0.34
1.800
100.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
2
C6H12N2O3
160.17
6.02
-0
-0.34
1.800
160.1706
160.0845
Self-Assembly Information 3 records
Record 1 Selfassembly

Source

23915244
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Nanoribbon Left handed twisted Nanoribbon
temperature: Room temperature solvent: Water concentration: 20mg/ml
Selfassembly; Nanostructure=Nanoribbon; Left handed twisted Nanoribbon; Trigger=temperature: Room temperature; solvent: Water; concentration: 20mg/ml
FE - SEM (Field Emission Scanning Electron Microscopy or FE - SEM)
Selfassembly
Record 2 Selfassembly

Source

23915244
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Nanoribbon Right handed Nanoribbon
temperature: Room temperature solvent: Tetrahydrofuran (THF) concentration: 30mg/ml
Selfassembly; Nanostructure=Nanoribbon; Right handed Nanoribbon; Trigger=temperature: Room temperature; solvent: Tetrahydrofuran (THF); concentration: 30mg/ml
FE - SEM (Field Emission Scanning Electron Microscopy or FE - SEM)
Selfassembly
Record 3 Selfassembly

Source

29138048
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Nanoparticle Nanoparticles
Selfassembly; Nanostructure=Nanoparticle; Nanoparticles
Scanning Electron Microscopy (SEM)
Selfassembly
Evidence Records 7 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
620.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Cushman D. W.
Angiotensin converting enzyme inhibitors: Evolution of a new class of antihypertensive drugs (page 19). in: Horovitz Z. P. (Ed.)(1981), Mechanisms of action and clinical implications, Urban & Schwarzenberg.
1981
book

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](C)C(=O)N[C@@H](C)C(=O)O InChI=1S/C6H12N2O3/c1-3(7)5(9)8-4(2)6(10)11/h3-4H,7H2,1-2H3,(H,8,9)(H,10,11)/t3-,4-/m0/s1 InChIKey: DEFJQIDDEAULHB-IMJSIDKUSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8637) the BRENDA database the EROP-Moscow database Inhibitor of Cytosol alanyl aminopeptidase (EC 3.4.11.14) (MEROPS ID: M24.005) according to he the BRENDA database Inhibitor of D-Ala-D-Ala Dipeptidase (EC 3.4.13.22) (MEROPS ID: M15.011) according to tBRENDA database Inhibitor of Peptide-transporting ATPase (EC 3.6.3.43) according to the BRENDA database Activator of Carbonic anhydrases (EC 4.2.1.1) according to the ChEMBL database Antibacterial peptide according to the ChEMBL database Hyp[otensive peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10141) Sweet peptide according to the BIOPEP-UWM database of sensory peptides and amino acids
Evidence 2 Activity

Activity

IC50
Antihypertensive
620.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Cushman D. W.
Angiotensin converting enzyme inhibitors: Evolution of a new class of antihypertensive drugs (page 19). in: Horovitz Z. P. (Ed.)(1981), Mechanisms of action and clinical implications, Urban & Schwarzenberg.
1981
book

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](C)C(=O)N[C@@H](C)C(=O)O InChI=1S/C6H12N2O3/c1-3(7)5(9)8-4(2)6(10)11/h3-4H,7H2,1-2H3,(H,8,9)(H,10,11)/t3-,4-/m0/s1 InChIKey: DEFJQIDDEAULHB-IMJSIDKUSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8637) the BRENDA database the EROP-Moscow database Inhibitor of Cytosol alanyl aminopeptidase (EC 3.4.11.14) (MEROPS ID: M24.005) according to he the BRENDA database Inhibitor of D-Ala-D-Ala Dipeptidase (EC 3.4.13.22) (MEROPS ID: M15.011) according to tBRENDA database Inhibitor of Peptide-transporting ATPase (EC 3.6.3.43) according to the BRENDA database Activator of Carbonic anhydrases (EC 4.2.1.1) according to the ChEMBL database Antibacterial peptide according to the ChEMBL database Hyp[otensive peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10141) Sweet peptide according to the BIOPEP-UWM database of sensory peptides and amino acids
Evidence 3 Activity

Activity

EC50
Antihypertensive
0.00 µM
Peptide lowering blood pressure in rats
hypotensive
hyp

Source & Reference

AHTPDB
Heres A., Yokoyama I., Gallego M., Toldrá F., Arihara K., Mora L.
Antihypertensive potential of sweet Ala-Ala dipeptide and its quantitation in dry-cured ham at different processing conditions. J. Funct. Foods, 87, 104818, 2021
2021
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](C)C(=O)N[C@@H](C)C(=O)O InChI=1S/C6H12N2O3/c1-3(7)5(9)8-4(2)6(10)11/h3-4H,7H2,1-2H3,(H,8,9)(H,10,11)/t3-,4-/m0/s1 InChIKey: DEFJQIDDEAULHB-IMJSIDKUSA-N Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database the BIOPEP-UWM database of bioactive peptides (ID 7590), the BRENDA database the ChEMBL database Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP database of bioactive peptides (ID 8637) the BRENDA database the EROP-Moscow database Inhibitor of Cytosol alanyl aminopeptidase (EC 3.4.11.14) (MEROPS ID: M24.005) according to the BRENDA database Inhibitor of D-Ala-D-Ala Dipeptidase (EC 3.4.13.22) (MEROPS ID: M15.011) according to the BRENDA database Inhibitor of Peptide-transporting ATPase (EC 3.6.3.43) according to the BRENDA database Activator of Carbonic anhydrases (EC 4.2.1.1) according to the ChEMBL database Antibacterial peptide according to the ChEMBL database Sweet peptide according to the BIOPEP-UWM database of sensory peptides and amino acids
Evidence 4 Activity

Activity

IC50
iDPPIV
9400.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Gallego M., Aristoy M.-C., Toldrá F.
Dipeptidyl peptidase IV inhibitory peptides generated in Spanish dry-cured ham. Meat Science 96, 757-761, 2014
2014
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](C)C(=O)N[C@@H](C)C(=O)O InChI=1S/C6H12N2O3/c1-3(7)5(9)8-4(2)6(10)11/h3-4H,7H2,1-2H3,(H,8,9)(H,10,11)/t3-,4-/m0/s1 InChIKey: DEFJQIDDEAULHB-IMJSIDKUSA-N Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database the BIOPEP-UWM database of bioactive peptides (ID 7590), the BRENDA database the ChEMBL database Inhibitor of Cytosol alanyl aminopeptidase (EC 3.4.11.14) (MEROPS ID: M24.005) according to the BRENDA database Inhibitor of D-Ala-D-Ala Dipeptidase (EC 3.4.13.22) (MEROPS ID: M15.011) according to the BRENDA database Inhibitor of Peptide-transporting ATPase (EC 3.6.3.43) according to the BRENDA database Activator of Carbonic anhydrases (EC 4.2.1.1) according to the ChEMBL database Antibacterial peptide according to the ChEMBL database Hypotensive peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10141) Sweet peptide according to the BIOPEP-UWM database of sensory peptides and amino acids
Evidence 5 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Nanoribbon Left handed twisted Nanoribbon Trigger=temperature: Room temperature solvent: Water concentration: 20mg/ml
Nanoribbon Left handed twisted Nanoribbon

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
temperature: Room temperature solvent: Water concentration: 20mg/ml
FE - SEM (Field Emission Scanning Electron Microscopy or FE - SEM)
23915244
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
Evidence 6 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Nanoribbon Right handed Nanoribbon Trigger=temperature: Room temperature solvent: Tetrahydrofuran (THF) concentration: 30mg/ml
Nanoribbon Right handed Nanoribbon

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
temperature: Room temperature solvent: Tetrahydrofuran (THF) concentration: 30mg/ml
FE - SEM (Field Emission Scanning Electron Microscopy or FE - SEM)
23915244
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
Evidence 7 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Nanoparticle Nanoparticles
Nanoparticle Nanoparticles

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
Scanning Electron Microscopy (SEM)
29138048
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
Additional Detail Fields 6 fields
temperature: Room temperature solvent: Water concentration: 20mg/ml solvent: Tetrahydrofuran (THF) concentration: 30mg/ml
None specified
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
2
23915244 29138048
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly