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Peptide record

TPDB48046

ACE inhibitor from Alaskan pollack skin ACE inhibitors Antihypertensive standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB48046
ACE inhibitor from Alaskan pollack skin
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB AHTpin
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
PGL
Physicochemical Analysis
C13H23N3O4
ARNDCEQHIKMFSTWYV
GLP
285.34
6.02
0
0
1
-0
-0.10
0.600
130.00
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
1
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
3
C13H23N3O4
285.34
6.02
-0
-0.10
0.600
285.3385
285.1683
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
13.93 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Byun H.-G., Kim S.-K.
Structure and activity of angiotensin I-converting enzyme inhibitory peptides derived from Alaskan pollack skin. Bioch. Mol. Biol., 35, 2, 239-243, 2002
2002
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: N1[C@H](C(=O)NCC(=O)N[C@H](C(=O)O)CC(C)C)CCC1 InChI=1S/C13H23N3O4/c1-8(2)6-10(13(19)20)16-11(17)7-15-12(18)9-4-3-5-14-9/h8-10,14H,3-7H2,1-2H3,(H,15,18)(H,16,17)(H,19,20)/t9-,10-/m0/s1 InChIKey: FKLSMYYLJHYPHH-UWVGGRQHSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
13.93 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Byun H.-G., Kim S.-K.
Structure and activity of angiotensin I-converting enzyme inhibitory peptides derived from Alaskan pollack skin. Bioch. Mol. Biol., 35, 2, 239-243, 2002
2002
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: N1[C@H](C(=O)NCC(=O)N[C@H](C(=O)O)CC(C)C)CCC1 InChI=1S/C13H23N3O4/c1-8(2)6-10(13(19)20)16-11(17)7-15-12(18)9-4-3-5-14-9/h8-10,14H,3-7H2,1-2H3,(H,15,18)(H,16,17)(H,19,20)/t9-,10-/m0/s1 InChIKey: FKLSMYYLJHYPHH-UWVGGRQHSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
3