TPDB

3D PDB MODEL

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TPDB ID TPDB48044

Peptide_Name

ACE inhibitor from porcine hemoglobin

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 5-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.

Sequence

WVPSV

FASTA

>TPDB48044|ACE inhibitors;Antihypertensive|length=5
WVPSV

Formula C29H42N6O7

Absent Amino Acids ARNDCEQGHILKMFTY

Common Amino Acids V

Mass 586.69

PI 6.02

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 3

Net Charge -0

Boman Index -1.13

Hydrophobicity 1.020

Aliphatic Index 116.00

Half Life

Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 5500

Absorbance 280nm 937.46

Polar Residues 1

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

0

L

0

K

0

M

0

F

1

P

1

S

0

T

1

W

0

Y

2

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 1 T: 0 W: 1 Y: 0 V: 2

Length

5

Formula

C29H42N6O7

Mass

586.69

PI

6.02

Net Charge

-0

Boman Index

-1.13

Hydrophobicity

1.020

Chemical_Mass

586.6781

Monoisotopic_Mass

586.3105

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 0.37 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Ren Y., Wan D.-G., Lu X., Chen L., Zhang T., Guo J.-L.

Title

Isolation and characterization of angiotensin Iconverting enzyme inhibitor peptides derived from porcine hemoglobin. Scientific Research and Essays 6(30), 6262-6269, DOI: 10.5897/SRE11.326.

Year 2011

Literature Source Journal

Other

Number of Residues 5

Additional Info Activity expressed in (mg/ml).

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 0.37 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Ren Y., Wan D.-G., Lu X., Chen L., Zhang T., Guo J.-L.

Title

Isolation and characterization of angiotensin Iconverting enzyme inhibitor peptides derived from porcine hemoglobin. Scientific Research and Essays 6(30), 6262-6269, DOI: 10.5897/SRE11.326.

Year 2011

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 5

Additional Info Activity expressed in (mg/ml).

Number_of_Residues

5