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Peptide record

TPDB48037

ACE inhibitor ACE inhibitors Antihypertensive standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB48037
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB AHTpin
standard
No
A 5-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
RVPSL
Physicochemical Analysis
C25H46N8O7
ANDCEQGHIKMFTWY
RLPSV
570.69
11.05
1
0
2
+1
0.90
0.220
136.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
0
K
0
M
0
F
1
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
5
C25H46N8O7
570.69
11.05
+1
0.90
0.220
570.6803
570.3479
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
20.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Liu J. B., Yu Z. P., Zhao W. Z., Lin S. Y., Wang E. L., Zhang Y., Hao Y., Wang Z. Z., Chen F.
Isolation and identification of angiotensin-converting enzyme inhibitory peptides from egg-white protein hydrolysates. Food Chem., 2010, 122:1159-1163.
2010
Journal

Other

5
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCCNC(N)=N)C(=O)N[C@@]([H])(C(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(O)=O InChI=1S/C25H46N8O7/c1-13(2)11-16(24(39)40)30-21(36)17(12-34)31-22(37)18-8-6-10-33(18)23(38)19(14(3)4)32-20(35)15(26)7-5-9-29-25(27)28/h13-19,34H,5-12,26H2,1-4H3,(H,30,36)(H,31,37)(H,32,35)(H,39,40)(H4,27,28,29)/t15-,16-,17-,18-,19-/m0/s1 InChIKey: IARUETPWBSYXJQ-VMXHOPILSA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
20.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Liu J. B., Yu Z. P., Zhao W. Z., Lin S. Y., Wang E. L., Zhang Y., Hao Y., Wang Z. Z., Chen F.
Isolation and identification of angiotensin-converting enzyme inhibitory peptides from egg-white protein hydrolysates. Food Chem., 2010, 122:1159-1163.
2010
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
5
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCCNC(N)=N)C(=O)N[C@@]([H])(C(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(O)=O InChI=1S/C25H46N8O7/c1-13(2)11-16(24(39)40)30-21(36)17(12-34)31-22(37)18-8-6-10-33(18)23(38)19(14(3)4)32-20(35)15(26)7-5-9-29-25(27)28/h13-19,34H,5-12,26H2,1-4H3,(H,30,36)(H,31,37)(H,32,35)(H,39,40)(H4,27,28,29)/t15-,16-,17-,18-,19-/m0/s1 InChIKey: IARUETPWBSYXJQ-VMXHOPILSA-N
Additional Detail Fields 1 fields
5