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Peptide record

TPDB48035

ACE inhibitor ACE inhibitors Antihypertensive standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB48035
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB AHTpin
standard
No
A 4-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
RPYL
Physicochemical Analysis
C26H41N7O6
ANDCEQGHIKMFSTWV
RLPY
547.65
9.88
1
0
2
+1
-0.24
-0.900
97.50
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
1490
272.07
1
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
4
C26H41N7O6
547.65
9.88
+1
-0.24
-0.900
547.6454
547.3109
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
56.50 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Ruiz-Giménez P., Salom J. B., Marcos J. F., Valles S., Martinez-Maqueda D., Recio I., Torregrosa G., Alborch E., Manzanares P.
Antihypertensive effect of a bovine lactoferrin pepsin hydrolysate: Identification of novel active peptides. Food Chem., 131, 266-273, 2012
2012
Journal

Other

4
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCCNC(=N)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)O InChI=1S/C26H41N7O6/c1-15(2)13-20(25(38)39)32-22(35)19(14-16-7-9-17(34)10-8-16)31-23(36)21-6-4-12-33(21)24(37)18(27)5-3-11-30-26(28)29/h7-10,15,18-21,34H,3-6,11-14,27H2,1-2H3,(H,31,36)(H,32,35)(H,38,39)(H4,28,29,30)/t18-,19-,20-,21-/m0/s1 InChIKey: QJSQUJBOQKFSCU-TUFLPTIASA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
56.50 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Ruiz-Giménez P., Salom J. B., Marcos J. F., Valles S., Martinez-Maqueda D., Recio I., Torregrosa G., Alborch E., Manzanares P.
Antihypertensive effect of a bovine lactoferrin pepsin hydrolysate: Identification of novel active peptides. Food Chem., 131, 266-273, 2012
2012
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
4
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCCNC(=N)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)O InChI=1S/C26H41N7O6/c1-15(2)13-20(25(38)39)32-22(35)19(14-16-7-9-17(34)10-8-16)31-23(36)21-6-4-12-33(21)24(37)18(27)5-3-11-30-26(28)29/h7-10,15,18-21,34H,3-6,11-14,27H2,1-2H3,(H,31,36)(H,32,35)(H,38,39)(H4,28,29,30)/t18-,19-,20-,21-/m0/s1 InChIKey: QJSQUJBOQKFSCU-TUFLPTIASA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
4