Back to search

Peptide record

TPDB48034

ACE inhibitor ACE inhibitors Antihypertensive standard
5 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB48034
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB AHTpin
standard
No
A 5-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
LIWKL
Physicochemical Analysis
C35H57N7O6
ARNDCEQGHMFPSTYV
L
671.88
10.10
1
0
4
+1
-2.29
1.460
234.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
5500
818.60
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
2
L
1
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 2 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
5
C35H57N7O6
671.88
10.10
+1
-2.29
1.460
671.8681
671.4357
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
0.47 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Ruiz-Giménez P., Salom J. B., Marcos J. F., Valles S., Martinez-Maqueda D., Recio I., Torregrosa G., Alborch E., Manzanares P.
Antihypertensive effect of a bovine lactoferrin pepsin hydrolysate: Identification of novel active peptides. Food Chem., 131, 266-273, 2012
2012
Journal

Other

5
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1c2ccccc2[nH]c1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O InChI=1S/C35H57N7O6/c1-7-22(6)30(42-31(43)25(37)16-20(2)3)34(46)40-28(18-23-19-38-26-13-9-8-12-24(23)26)33(45)39-27(14-10-11-15-36)32(44)41-29(35(47)48)17-21(4)5/h8-9,12-13,19-22,25,27-30,38H,7,10-11,14-18,36-37H2,1-6H3,(H,39,45)(H,40,46)(H,41,44)(H,42,43)(H,47,48)/t22-,25-,27-,28-,29-,30-/m0/s1 InChIKey: DVGVKGVPVPRABU-KHDOVFMSSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
0.47 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Ruiz-Giménez P., Salom J. B., Marcos J. F., Valles S., Martinez-Maqueda D., Recio I., Torregrosa G., Alborch E., Manzanares P.
Antihypertensive effect of a bovine lactoferrin pepsin hydrolysate: Identification of novel active peptides. Food Chem., 131, 266-273, 2012
2012
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
5
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1c2ccccc2[nH]c1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O InChI=1S/C35H57N7O6/c1-7-22(6)30(42-31(43)25(37)16-20(2)3)34(46)40-28(18-23-19-38-26-13-9-8-12-24(23)26)33(45)39-27(14-10-11-15-36)32(44)41-29(35(47)48)17-21(4)5/h8-9,12-13,19-22,25,27-30,38H,7,10-11,14-18,36-37H2,1-6H3,(H,39,45)(H,40,46)(H,41,44)(H,42,43)(H,47,48)/t22-,25-,27-,28-,29-,30-/m0/s1 InChIKey: DVGVKGVPVPRABU-KHDOVFMSSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
5