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Peptide record

TPDB48033

ACE inhibitor ACE inhibitors Antihypertensive standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB48033
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
FermFooDB Peptipedia AHTPDB AHTpin
standard
No
A 4-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from FermFooDB, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
PKHP
Physicochemical Analysis
C22H35N7O5
ARNDCEQGILMFSTWYV
P
477.56
10.10
2
0
0
+1
2.85
-2.575
0.00
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
1
H
0
I
0
L
1
K
0
M
0
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 0 K: 1 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
4
C22H35N7O5
477.56
10.10
+1
2.85
-2.575
477.5558
477.2692
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
709.10 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

FermFooDB
Gómez-Ruiz J.A., Taborda G., Amigo L., Recio I., Ramos M.
Identification of ACE-inhibitory peptides in different Spanish cheeses by tandem mass spectrometry. European Food Research and Technology, 2006, 223:595-601
2006
Journal

Other

4
BIOPEP-UWM database of bioactive peptides SMILES: N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=C[N]([H])C=N2)C(=O)N3[C@@H](CCC3)C(=O)O InChI=1S/C22H35N7O5/c23-8-2-1-5-16(27-19(30)15-6-3-9-25-15)20(31)28-17(11-14-12-24-13-26-14)21(32)29-10-4-7-18(29)22(33)34/h12-13,15-18,25H,1-11,23H2,(H,24,26)(H,27,30)(H,28,31)(H,33,34)/t15-,16-,17-,18-/m0/s1 InChIKey: CIBMHNARXJUMIG-XSLAGTTESA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
709.10 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB FermFooDB
Gómez-Ruiz J.A., Taborda G., Amigo L., Recio I., Ramos M.
Identification of ACE-inhibitory peptides in different Spanish cheeses by tandem mass spectrometry. European Food Research and Technology, 2006, 223:595-601
2006
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
4
BIOPEP-UWM database of bioactive peptides SMILES: N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=C[N]([H])C=N2)C(=O)N3[C@@H](CCC3)C(=O)O InChI=1S/C22H35N7O5/c23-8-2-1-5-16(27-19(30)15-6-3-9-25-15)20(31)28-17(11-14-12-24-13-26-14)21(32)29-10-4-7-18(29)22(33)34/h12-13,15-18,25H,1-11,23H2,(H,24,26)(H,27,30)(H,28,31)(H,33,34)/t15-,16-,17-,18-/m0/s1 InChIKey: CIBMHNARXJUMIG-XSLAGTTESA-N
Additional Detail Fields 1 fields
4