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Peptide record

TPDB48032

ACE inhibitor ACE inhibitors Antidiabetic Antihypertensive Bitter standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB48032
ACE inhibitor
ACE inhibitors Antidiabetic Antihypertensive Bitter
Cardiometabolic peptides Food sensory peptides
FermFooDB Peptipedia AHTPDB AHTpin Tastepeptides-Meta
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors, Antidiabetic, Antihypertensive, and other sources) peptide sequence curated from FermFooDB, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
PFP
Physicochemical Analysis
C19H25N3O4
ARNDCEQGHILKMSTWYV
P
359.43
6.02
0
0
1
-0
-0.23
-0.133
0.00
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
1
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
3
C19H25N3O4
359.43
6.02
-0
-0.23
-0.133
359.4185
359.1839
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
144.40 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

FermFooDB
Gómez-Ruiz J.A., Taborda G., Amigo L., Recio I., Ramos M.
Identification of ACE-inhibitory peptides in different Spanish cheeses by tandem mass spectrometry. European Food Research and Technology, 2006, 223:595-601
2006
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C19H25N3O4/c23-17(14-8-4-10-20-14)21-15(12-13-6-2-1-3-7-13)18(24)22-11-5-9-16(22)19(25)26/h1-3,6-7,14-16,20H,4-5,8-12H2,(H,21,23)(H,25,26)/t14-,15-,16-/m0/s1 InChIKey: ZVEQWRWMRFIVSD-JYJNAYRXSA-N Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 69)
Evidence 2 Activity

Activity

IC50
Antihypertensive
144.40 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB FermFooDB
Gómez-Ruiz J.A., Taborda G., Amigo L., Recio I., Ramos M.
Identification of ACE-inhibitory peptides in different Spanish cheeses by tandem mass spectrometry. European Food Research and Technology, 2006, 223:595-601
2006
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C19H25N3O4/c23-17(14-8-4-10-20-14)21-15(12-13-6-2-1-3-7-13)18(24)22-11-5-9-16(22)19(25)26/h1-3,6-7,14-16,20H,4-5,8-12H2,(H,21,23)(H,25,26)/t14-,15-,16-/m0/s1 InChIKey: ZVEQWRWMRFIVSD-JYJNAYRXSA-N Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 69)
Additional Detail Fields 1 fields
3