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Peptide record

TPDB48027

ACE inhibitor ACE inhibitors Antihypertensive standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB48027
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB AHTpin
standard
No
A 4-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
VRSP
Physicochemical Analysis
C19H35N7O6
ANDCEQGHILKMFTWY
RPSV
457.53
11.05
1
0
1
+1
1.46
-0.675
72.50
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
1
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
4
C19H35N7O6
457.53
11.05
+1
1.46
-0.675
457.5231
457.2641
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
2018.27 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

NA
Wang Z., Zhang S., Wang W., Feng F., Shan W.
A novel angiotensin I converting enzyme inhibitory peptide from the milk casein: virtual screening and docking studies. Agric. Sci. China, 10, 463-467, 2011
2011
Journal

Other

4
Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
2018.27 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Wang Z., Zhang S., Wang W., Feng F., Shan W.
A novel angiotensin I converting enzyme inhibitory peptide from the milk casein: virtual screening and docking studies. Agric. Sci. China, 10, 463-467, 2011
2011
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
4
Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001
Additional Detail Fields 1 fields
4