TPDB

3D PDB MODEL

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TPDB ID TPDB48014

Peptide_Name

ACE inhibitor Hypotensive peptide

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 3-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.

Sequence

GVW

FASTA

>TPDB48014|ACE inhibitors;Antihypertensive|length=3
GVW

Formula C18H24N4O4

Absent Amino Acids ARNDCEQHILKMFPSTY

Common Amino Acids GWV

Mass 360.41

PI 6.02

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 2

Net Charge -0

Boman Index -1.77

Hydrophobicity 0.967

Aliphatic Index 96.67

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 5500

Absorbance 280nm 1526.03

Polar Residues 0

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

1

G

0

H

0

I

0

L

0

K

0

M

0

F

0

P

0

S

0

T

1

W

0

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 1

Length

3

Formula

C18H24N4O4

Mass

360.41

PI

6.02

Net Charge

-0

Boman Index

-1.77

Hydrophobicity

0.967

Chemical_Mass

360.4066

Monoisotopic_Mass

360.1792

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 240.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Chen G. W., Tsai J. S., Pan B. S.

Title

Purification of angiotensin I-converting inhibitory peptides and antihypertensive effect of milk produced by protease-facilitate lactic fermentation. Int. Dairy J., 2007, 17, 641-647

Year 2007

Literature Source Journal

Other

Number of Residues 3

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: NCC(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)O InChI=1S/C18H24N4O4/c1-10(2)16(22-15(23)8-19)17(24)21-14(18(25)26)7-11-9-20-13-6-4-3-5-12(11)13/h3-6,9-10,14,16,20H,7-8,19H2,1-2H3,(H,21,24)(H,22,23)(H,25,26)/t14-,16-/m0/s1 InChIKey=COZMNNJEGNPDED-HOCLYGCPSA-N Hypouricemic peptide according to the BIOPEP-UWM database of bioactive peptides Hypotensive peptide according to the BIOPEP-UWM database of bioactive peptides the DFBP database

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 240.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Chen G. W., Tsai J. S., Pan B. S.

Title

Purification of angiotensin I-converting inhibitory peptides and antihypertensive effect of milk produced by protease-facilitate lactic fermentation. Int. Dairy J., 2007, 17, 641-647

Year 2007

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 3

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: NCC(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)O InChI=1S/C18H24N4O4/c1-10(2)16(22-15(23)8-19)17(24)21-14(18(25)26)7-11-9-20-13-6-4-3-5-12(11)13/h3-6,9-10,14,16,20H,7-8,19H2,1-2H3,(H,21,24)(H,22,23)(H,25,26)/t14-,16-/m0/s1 InChIKey=COZMNNJEGNPDED-HOCLYGCPSA-N Hypouricemic peptide according to the BIOPEP-UWM database of bioactive peptides Hypotensive peptide according to the BIOPEP-UWM database of bioactive peptides the DFBP database

Evidence 3 Activity

Activity

Activity Endpoint EC50

Detail Source Activity Antihypertensive

Activity Measurement 0.00 µM

Function Lowering blood pressure in rats

Detail Activity hypotensive

Activity Code hyp

Source & Reference

Database Source AHTPDB

Authors Chen G. W., Tsai J. S., Pan B. S.

Title

Purification of angiotensin I-converting inhibitory peptides and antihypertensive effect of milk produced by protease-facilitate lactic fermentation. Int. Dairy J., 2007, 17, 641-647

Year 2007

Literature Source Journal

Other

Number of Residues 3

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: NCC(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)O InChI=1S/C18H24N4O4/c1-10(2)16(22-15(23)8-19)17(24)21-14(18(25)26)7-11-9-20-13-6-4-3-5-12(11)13/h3-6,9-10,14,16,20H,7-8,19H2,1-2H3,(H,21,24)(H,22,23)(H,25,26)/t14-,16-/m0/s1 InChIKey=COZMNNJEGNPDED-HOCLYGCPSA-N Hypouricemic peptide according to the BIOPEP-UWM database of bioactive peptides Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database the BIOPEP-UWM database of bioactive peptides (ID 7491) the DFBP database the EROP-Moscow database

Number_of_Residues

3