TPDB

3D PDB MODEL

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TPDB ID TPDB48010

Peptide_Name

ACE inhibitor Renin inhibitor

Activity

ACE inhibitors Anti-inflammatory Antihypertensive

Activity_category_statistics

Cardiometabolic peptides Immunity and inflammation peptides

Database_Source

Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 4-aa standard natural multi-activity (ACE inhibitors, Anti-inflammatory, and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.

Sequence

RALP

FASTA

>TPDB48010|ACE inhibitors;Anti-inflammatory;Antihypertensive|length=4
RALP

Formula C20H37N7O5

Absent Amino Acids NDCEQGHIKMFSTWYV

Common Amino Acids ARLP

Mass 455.56

PI 11.05

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 2

Net Charge +1

Boman Index 0.53

Hydrophobicity -0.125

Aliphatic Index 122.50

Half Life

Mammalian: 1 hour Yeast: 2 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

1

A

1

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

1

L

0

K

0

M

0

F

1

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

4

Formula

C20H37N7O5

Mass

455.56

PI

11.05

Net Charge

+1

Boman Index

0.53

Hydrophobicity

-0.125

Chemical_Mass

455.5502

Monoisotopic_Mass

455.2848

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 650.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors He R., Malomo S. A., Alashi A., Girgih A. T., Ju X., Aluko R. E.

Title

Purification and hypotensive activity of rapeseed protein derived renin and angiotensin converting enzyme inhibitory peptides. J. Funct. Foods, 5, 781-789, 2013

Year 2013

Literature Source Journal

Other

Number of Residues 4

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C20H37N7O5/c1-11(2)10-14(18(30)27-9-5-7-15(27)19(31)32)26-16(28)12(3)25-17(29)13(21)6-4-8-24-20(22)23/h11-15H,4-10,21H2,1-3H3,(H,25,29)(H,26,28)(H,31,32)(H4,22,23,24)/t12-,13-,14-,15-/m0/s1 InChIKey: DLIFANHAVQERII-AJNGGQMLSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Inhibitor of Renin (EC 3.4.23.15) (MEROPS ID: A01.007) according to the BIOPEP-UWM database of bioactive peptides (ID: 9469)

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 650.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors He R., Malomo S. A., Alashi A., Girgih A. T., Ju X., Aluko R. E.

Title

Purification and hypotensive activity of rapeseed protein derived renin and angiotensin converting enzyme inhibitory peptides. J. Funct. Foods, 5, 781-789, 2013

Year 2013

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 4

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C20H37N7O5/c1-11(2)10-14(18(30)27-9-5-7-15(27)19(31)32)26-16(28)12(3)25-17(29)13(21)6-4-8-24-20(22)23/h11-15H,4-10,21H2,1-3H3,(H,25,29)(H,26,28)(H,31,32)(H4,22,23,24)/t12-,13-,14-,15-/m0/s1 InChIKey: DLIFANHAVQERII-AJNGGQMLSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Inhibitor of Renin (EC 3.4.23.15) (MEROPS ID: A01.007) according to the BIOPEP-UWM database of bioactive peptides (ID: 9469)

Evidence 3 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 970.00 µM

Function Inhibitor of Renin (EC 3.4.23.15) (MEROPS ID A01.007)

Detail Activity renin inhibitor

Activity Code ren

Source & Reference

Database Source AHTPDB

Authors He R., Malomo S. A., Alashi A., Girgih A. T., Ju X., Aluko R. E.

Title

Purification and hypotensive activity of rapeseed protein derived renin and angiotensin converting enzyme inhibitory peptides. J. Funct. Foods, 5, 781-789, 2013

Year 2013

Literature Source Journal

Other

Number of Residues 4

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C20H37N7O5/c1-11(2)10-14(18(30)27-9-5-7-15(27)19(31)32)26-16(28)12(3)25-17(29)13(21)6-4-8-24-20(22)23/h11-15H,4-10,21H2,1-3H3,(H,25,29)(H,26,28)(H,31,32)(H4,22,23,24)/t12-,13-,14-,15-/m0/s1 InChIKey: DLIFANHAVQERII-AJNGGQMLSA-N Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database the BIOPEP-UWM database of bioactive peptides (ID: 9468)

Number_of_Residues

4