TPDB

3D PDB MODEL

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TPDB ID TPDB47998

Peptide_Name

ACE inhibitor

Activity

Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

AHTPDB AHTpin Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 3-aa standard natural antihypertensive peptide sequence curated from AHTPDB, AHTpin, and Peptipedia, with an available 3D structural model.

Sequence

VKK

FASTA

>TPDB47998|Antihypertensive|length=3
VKK

Formula C17H35N5O4

Absent Amino Acids ARNDCEQGHILMFPSTWY

Common Amino Acids K

Mass 373.50

PI 10.60

Basic Residues 2

Acidic Residues 0

Hydrophobic Residues 1

Net Charge +2

Boman Index 2.05

Hydrophobicity -1.200

Aliphatic Index 96.67

Half Life

Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

0

L

2

K

0

M

0

F

0

P

0

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1

Length

3

Formula

C17H35N5O4

Mass

373.50

PI

10.60

Net Charge

+2

Boman Index

2.05

Hydrophobicity

-1.200

Chemical_Mass

373.4895

Monoisotopic_Mass

373.2681

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 1045.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Tsai J. S., Lin T. C., Chen J. L., Pan B. S.

Title

The inhibitory effects of freshwater clam (Corbicula fluminea, Muller) muscle protein hydrolysates on angiotensin I converting enzyme. Process Biochem., 41, 2276-2281, 2006

Year 2006

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 3

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)O InChI=1S/C17H35N5O4/c1-11(2)14(20)16(24)21-12(7-3-5-9-18)15(23)22-13(17(25)26)8-4-6-10-19/h11-14H,3-10,18-20H2,1-2H3,(H,21,24)(H,22,23)(H,25,26)/t12-,13-,14-/m0/s1 InChIKey=YMTOEGGOCHVGEH-IHRRRGAJSA-N Activator of Angiotensin 2-converting enzyme (ACE2) (EC 3.4.17.23) (MEROPS ID: M02.006) according to the BIOPEP-UWM database of bioactive peptides

Number_of_Residues

3