Back to search

Peptide record

TPDB47992

ACE inhibitor ACE inhibitors Antihypertensive standard
3 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB47992
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB AHTpin
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
MAP
Physicochemical Analysis
C13H23N3O4S1
RNDCEQGHILKFSTWYV
AMP
317.40
6.02
0
0
2
-0
0.05
0.700
33.33
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
1
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 1 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
3
C13H23N3O4S1
317.40
6.02
-0
0.05
0.700
317.4046
317.1404
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
0.80 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Tonouchi H., Suzuki M., Uchida M., Oda M.
Antihypertensive effect of an angiotensin converting enzyme inhibitory peptide from enzyme modified cheese, J. Dairy Res. 75 (2008) 284-290.
2008
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCSC)C(=O)N[C@@]([H])(C)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C13H23N3O4S/c1-8(15-11(17)9(14)5-7-21-2)12(18)16-6-3-4-10(16)13(19)20/h8-10H,3-7,14H2,1-2H3,(H,15,17)(H,19,20)/t8-,9-,10-/m0/s1 InChIKey=ULNXMMYXQKGNPG-GUBZILKMSA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
0.80 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Tonouchi H., Suzuki M., Uchida M., Oda M.
Antihypertensive effect of an angiotensin converting enzyme inhibitory peptide from enzyme modified cheese, J. Dairy Res. 75 (2008) 284-290.
2008
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCSC)C(=O)N[C@@]([H])(C)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C13H23N3O4S/c1-8(15-11(17)9(14)5-7-21-2)12(18)16-6-3-4-10(16)13(19)20/h8-10H,3-7,14H2,1-2H3,(H,15,17)(H,19,20)/t8-,9-,10-/m0/s1 InChIKey=ULNXMMYXQKGNPG-GUBZILKMSA-N
Additional Detail Fields 1 fields
3