TPDB

3D PDB MODEL

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TPDB ID TPDB47978

Peptide_Name

ACE inhibitor

Activity

Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

AHTPDB Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 3-aa standard natural antihypertensive peptide sequence curated from AHTPDB and Peptipedia, with an available 3D structural model.

Sequence

GPR

FASTA

>TPDB47978|Antihypertensive|length=3
GPR

Formula C13H24N6O4

Absent Amino Acids ANDCEQHILKMFSTWYV

Common Amino Acids RGP

Mass 328.37

PI 11.05

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 0

Net Charge +1

Boman Index 1.27

Hydrophobicity -2.167

Aliphatic Index 0.00

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

1

R

0

N

0

D

0

C

0

E

0

Q

1

G

0

H

0

I

0

L

0

K

0

M

0

F

1

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

3

Formula

C13H24N6O4

Mass

328.37

PI

11.05

Net Charge

+1

Boman Index

1.27

Hydrophobicity

-2.167

Chemical_Mass

328.3665

Monoisotopic_Mass

328.1854

Evidence 1 Activity

Activity

Activity Endpoint EC50

Detail Source Activity Antihypertensive

Activity Measurement 0.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Escudero E., Sentandreu M. A., Arihara K., Toldrá F.

Title

Angiotensin I-converting enzyme inhibitory peptides generated from in vitro gastrointestinal digestion of pork meat. J. Agric. Food Chem., 58, 2895-2901, 2010

Year 2010

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 3

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](CCCNC(N)=N)(NC(=O)[C@]1([H])CCCN1C(=O)CN)C(O)=O InChI=1S/C13H24N6O4/c14-7-10(20)19-6-2-4-9(19)11(21)18-8(12(22)23)3-1-5-17-13(15)16/h8-9H,1-7,14H2,(H,18,21)(H,22,23)(H4,15,16,17)/t8-,9-/m0/s1 InChIKey=JYPCXBJRLBHWME-IUCAKERBSA-N Neuroprotective peptide according to the ChEMBL database Antithrombotic peptide according to the BIOPEP-UWM database of bioactive peptides (ID 3047), the DFBP database Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides

Number_of_Residues

3