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Peptide record

TPDB47973

ACE inhibitor Hypotensive peptide ACE inhibitors Antihypertensive Neuropeptide standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB47973
ACE inhibitor Hypotensive peptide
ACE inhibitors Antihypertensive Neuropeptide
Cardiometabolic peptides Neuroactive peptides
Peptipedia AHTPDB AHTpin
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Neuropeptide) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
ER
Physicochemical Analysis
C11H21N5O5
ANDCQGHILKMFPSTWYV
RE
303.32
6.97
1
1
0
-0
2.83
-4.000
0.00
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
1
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
2
C11H21N5O5
303.32
6.97
-0
2.83
-4.000
303.3141
303.1538
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
270.00 µM
Inhibitor of angiotensin-converting enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Escudero E, Sentandreu MA, Arihara K, Toldrá F.
Angiotensin I-converting enzyme inhibitory peptides generated from in vitro gastrointestinal digestion of pork meat. J. Agric. Food Chem., 58, 2895-2901, 2010
2010
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)O InChI= 1S/C11H21N5O5/c12-6(3-4-8(17)18)9(19)16-7(10(20)21)2-1-5-15-11(13)14/h6-7H,1-5,12H2,(H,16,19)(H,17,18)(H,20,21)(H4,13,14,15)/t6-,7-/m0/s1 InChIKey: MPZWMIIOPAPAKE-BQBZGAKWSA-N IC50 according to Lafarga et al. (2016). Food Res Int. 81, 91-99
Evidence 2 Activity

Activity

IC50
Antihypertensive
270.00 µM
Inhibitor of angiotensin-converting enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Escudero E, Sentandreu MA, Arihara K, Toldrá F.
Angiotensin I-converting enzyme inhibitory peptides generated from in vitro gastrointestinal digestion of pork meat. J. Agric. Food Chem., 58, 2895-2901, 2010
2010
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)O InChI= 1S/C11H21N5O5/c12-6(3-4-8(17)18)9(19)16-7(10(20)21)2-1-5-15-11(13)14/h6-7H,1-5,12H2,(H,16,19)(H,17,18)(H,20,21)(H4,13,14,15)/t6-,7-/m0/s1 InChIKey: MPZWMIIOPAPAKE-BQBZGAKWSA-N IC50 according to Lafarga et al. (2016). Food Res Int. 81, 91-99
Evidence 3 Activity

Activity

EC50
Antihypertensive
0.00 µM
Lowering blood pressure in rats
hypotensive
hyp

Source & Reference

AHTPDB
Lafarga T., Aluko R. E., Rai D. K., O'Connor P., Hayes M.
Identification of bioactive peptides from a papain hydrolysate of bovine serum albumin and assessment of an antihypertensive effect in spontaneously hypertensive rats. Food Res. Int., 81, 91-99, 2016
2016
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)O InChI= 1S/C11H21N5O5/c12-6(3-4-8(17)18)9(19)16-7(10(20)21)2-1-5-15-11(13)14/h6-7H,1-5,12H2,(H,16,19)(H,17,18)(H,20,21)(H4,13,14,15)/t6-,7-/m0/s1 InChIKey=MPZWMIIOPAPAKE-BQBZGAKWSA-N Inhibitor of angiotensin I-converting enzyme (EC 3.4.15.1 MEROPS ID: M02-001) according to the AHTPDB database, the BIOPEP-UWM database of bioactive peptides (ID 9944), the DFBP database, the EROP-Moscow database Hypotensive peptide according to the DFBP database
Additional Detail Fields 1 fields
2