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Peptide record

TPDB47972

ACE inhibitor ACE inhibitors Antihypertensive standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB47972
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB AHTpin
standard
No
A 5-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
PLPLL
Physicochemical Analysis
C28H49N5O6
ARNDCEQGHIKMFSTWYV
L
551.73
6.02
0
0
3
-0
-0.78
1.640
234.00
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
3
L
0
K
0
M
0
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 3 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
5
C28H49N5O6
551.73
6.02
-0
-0.78
1.640
551.7166
551.3671
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
0.53 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Mao X.-Y., Ni J.-R., Sun W.-L., Hao P.-P., Fan L.
Value-added utilization of yak milk casein for the production of angiotensin-I-converting enzyme inhibitory peptides. Food Chem., 2007, 103:1282-1287.
2007
Journal

Other

5
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](CC(C)C)(NC(=O)[C@]([H])(CC(C)C)NC(=O)[C@]1([H])CCCN1C(=O)[C@]([H])(CC(C)C)NC(=O)[C@]1([H])CCCN1)C(O)=O InChI=1S/C28H49N5O6/c1-16(2)13-20(25(35)32-22(28(38)39)15-18(5)6)30-26(36)23-10-8-12-33(23)27(37)21(14-17(3)4)31-24(34)19-9-7-11-29-19/h16-23,29H,7-15H2,1-6H3,(H,30,36)(H,31,34)(H,32,35)(H,38,39)/t19-,20-,21-,22-,23-/m0/s1 InChIKey: OPOVRYNTDLCLJR-VUBDRERZSA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
0.53 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Mao X.-Y., Ni J.-R., Sun W.-L., Hao P.-P., Fan L.
Value-added utilization of yak milk casein for the production of angiotensin-I-converting enzyme inhibitory peptides. Food Chem., 2007, 103:1282-1287.
2007
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
5
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](CC(C)C)(NC(=O)[C@]([H])(CC(C)C)NC(=O)[C@]1([H])CCCN1C(=O)[C@]([H])(CC(C)C)NC(=O)[C@]1([H])CCCN1)C(O)=O InChI=1S/C28H49N5O6/c1-16(2)13-20(25(35)32-22(28(38)39)15-18(5)6)30-26(36)23-10-8-12-33(23)27(37)21(14-17(3)4)31-24(34)19-9-7-11-29-19/h16-23,29H,7-15H2,1-6H3,(H,30,36)(H,31,34)(H,32,35)(H,38,39)/t19-,20-,21-,22-,23-/m0/s1 InChIKey: OPOVRYNTDLCLJR-VUBDRERZSA-N
Additional Detail Fields 1 fields
5