TPDB

3D PDB MODEL

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TPDB ID TPDB47969

Peptide_Name

ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)

Activity

Antihypertensive iDPPIV

Activity_category_statistics

Cardiometabolic peptides

Database_Source

AHTPDB Peptipedia iDPPIV

Sequence_Type

standard

Has_Modification No

Description A 2-aa standard natural multi-activity (Antihypertensive and iDPPIV) peptide sequence curated from AHTPDB, Peptipedia, and iDPPIV, with an available 3D structural model.

Sequence

YQ

FASTA

>TPDB47969|Antihypertensive;iDPPIV|length=2
YQ

Formula C14H19N3O5

Absent Amino Acids ARNDCEGHILKMFPSTWV

Common Amino Acids QY

Mass 309.32

PI 5.94

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 1

Net Charge -0

Boman Index -0.36

Hydrophobicity -2.400

Aliphatic Index 0.00

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 1490

Absorbance 280nm 481.70

Polar Residues 2

number

0

A

0

R

0

N

0

D

0

C

0

E

1

Q

0

G

0

H

0

I

0

L

0

K

0

M

0

F

0

P

0

S

0

T

0

W

1

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0

Length

2

Formula

C14H19N3O5

Mass

309.32

PI

5.94

Net Charge

-0

Boman Index

-0.36

Hydrophobicity

-2.400

Chemical_Mass

309.3170

Monoisotopic_Mass

309.1320

Evidence 1 Activity

Activity

Activity Endpoint EC50

Detail Source Activity Antihypertensive

Activity Measurement 0.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Liu W.-Y., Zhang J.-T., Miyakawa T., Li G.-M., Gu R.-Z. Tanokura M.

Title

Antioxidant properties and inhibition of angiotensin‑converting enzyme by highly active peptides from wheat gluten. Sci. Rep., 11, 5206, 2021

Year 2021

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 2

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)O InChI=1S/C14H19N3O5/c15-10(7-8-1-3-9(18)4-2-8)13(20)17-11(14(21)22)5-6-12(16)19/h1-4,10-11,18H,5-7,15H2,(H2,16,19)(H,17,20)(H,21,22)/t10-,11-/m0/s1 InChIKey=UBAQSAUDKMIEQZ-QWRGUYRKSA-N Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8943) Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity iDPPIV

Activity Measurement 0.00 µM

Function Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)

Detail Activity dipeptidyl peptidase IV inhibitor

Activity Code dpp

Source & Reference

Database Source iDPPIV

Authors Lan V. T. T., Ito K., Ohno M., Motoyama T., Ito S., Kawarasaki Y.

Title Analyzing a dipeptide library to identify human dipeptidyl peptidase IV inhibitor. Food Chemistry 175, 66-73, 2015

Year 2015

Literature Source Journal

Other

Number of Residues 2

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)O InChI=1S/C14H19N3O5/c15-10(7-8-1-3-9(18)4-2-8)13(20)17-11(14(21)22)5-6-12(16)19/h1-4,10-11,18H,5-7,15H2,(H2,16,19)(H,17,20)(H,21,22)/t10-,11-/m0/s1 InChIKey=UBAQSAUDKMIEQZ-QWRGUYRKSA-N Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHJJTPDB database the BIOPEP-UWM database of bioactive peptides, the EROP-Moscow database, the PlantPepDB database Antioxidative peptide according to the bIOPEP-UWM databaase

Number_of_Residues

2