Back to search

Peptide record

TPDB47947

ACE inhibitor ACE inhibitors Antihypertensive standard
5 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB47947
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB AHTpin
standard
No
A 5-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
LALPP
Physicochemical Analysis
C25H43N5O6
RNDCEQGHIKMFSTWYV
LP
509.65
6.02
0
0
3
-0
-0.39
1.240
176.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
2
L
0
K
0
M
0
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 2 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
5
C25H43N5O6
509.65
6.02
-0
-0.39
1.240
509.6371
509.3203
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
0.00 µM
ACE inhibitor
ah

Source & Reference

NA
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human b-casein. Agric. Biol. Chem., 53, 2107-2114
1989
Journal

Other

5
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C25H43N5O6/c1-14(2)12-17(26)22(32)27-16(5)21(31)28-18(13-15(3)4)23(33)29-10-6-8-19(29)24(34)30-11-7-9-20(30)25(35)36/h14-20H,6-13,26H2,1-5H3,(H,27,32)(H,28,31)(H,35,36)/t16-,17-,18-,19-,20-/m0/s1 InChIKey=VHZIJPGVPYKSHP-HVTWWXFQSA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
0.00 µM
ACE inhibitor
ah

Source & Reference

AHTPDB
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human b-casein. Agric. Biol. Chem., 53, 2107-2114
1989
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
5
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C25H43N5O6/c1-14(2)12-17(26)22(32)27-16(5)21(31)28-18(13-15(3)4)23(33)29-10-6-8-19(29)24(34)30-11-7-9-20(30)25(35)36/h14-20H,6-13,26H2,1-5H3,(H,27,32)(H,28,31)(H,35,36)/t16-,17-,18-,19-,20-/m0/s1 InChIKey=VHZIJPGVPYKSHP-HVTWWXFQSA-N
Additional Detail Fields 1 fields
5