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Peptide record

TPDB47945

ACE inhibitors Antihypertensive standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB47945
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB AHTpin
standard
No
A 5-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
PKAIP
Physicochemical Analysis
C25H44N6O6
RNDCEQGHLMFSTWYV
P
524.66
10.10
1
0
2
+1
1.41
-0.160
98.00
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
0
L
1
K
0
M
0
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 0 K: 1 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
5
C25H44N6O6
524.66
10.10
+1
1.41
-0.160
524.6517
524.3312
Evidence Records 2 records
Evidence 1 Activity

Activity

EC50
ACE inhibitors
185.00 µM
ACE inhibitor
ah

Source & Reference

NA
Kohmura M., Nio N., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptide fragments of various beta-caseins. Agric.Biol.Chem. 54(4),1101-1102(1990)
1990
Journal

Other

5
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](C)(CC)[C@]([H])(NC(=O)[C@]([H])(C)NC(=O)[C@]([H])(CCCCN)NC(=O)[C@]1([H])CCCN1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C25H44N6O6/c1-4-15(2)20(24(35)31-14-8-11-19(31)25(36)37)30-21(32)16(3)28-23(34)18(9-5-6-12-26)29-22(33)17-10-7-13-27-17/h15-20,27H,4-14,26H2,1-3H3,(H,28,34)(H,29,33)(H,30,32)(H,36,37)/t15-,16-,17-,18-,19-,20-/m0/s1 InChIKey=JEVQUYWCYGDQPF-RABCQHRBSA-N
Evidence 2 Activity

Activity

EC50
Antihypertensive
185.00 µM
ACE inhibitor
ah

Source & Reference

AHTPDB
Kohmura M., Nio N., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptide fragments of various beta-caseins. Agric.Biol.Chem. 54(4),1101-1102(1990)
1990
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
5
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](C)(CC)[C@]([H])(NC(=O)[C@]([H])(C)NC(=O)[C@]([H])(CCCCN)NC(=O)[C@]1([H])CCCN1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C25H44N6O6/c1-4-15(2)20(24(35)31-14-8-11-19(31)25(36)37)30-21(32)16(3)28-23(34)18(9-5-6-12-26)29-22(33)17-10-7-13-27-17/h15-20,27H,4-14,26H2,1-3H3,(H,28,34)(H,29,33)(H,30,32)(H,36,37)/t15-,16-,17-,18-,19-,20-/m0/s1 InChIKey=JEVQUYWCYGDQPF-RABCQHRBSA-N
Additional Detail Fields 1 fields
5