Back to search

Peptide record

TPDB47944

ACE inhibitors Antihypertensive standard
5 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB47944
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB AHTpin
standard
No
A 5-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
PQAFP
Physicochemical Analysis
C27H38N6O7
RNDCEGHILKMSTWYV
P
558.63
6.02
0
0
2
-0
0.18
-0.420
20.00
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
0
0.00
1
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
0
I
0
L
0
K
0
M
1
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
5
C27H38N6O7
558.63
6.02
-0
0.18
-0.420
558.6251
558.2793
Evidence Records 2 records
Evidence 1 Activity

Activity

EC50
ACE inhibitors
300.00 µM
ACE inhibitor
ah

Source & Reference

NA
Kohmura M., Nio N., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptide fragments of various beta-caseins. Agric.Biol.Chem. 54(4),1101-1102(1990)
1990
Journal

Other

5
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](C)(NC(=O)[C@]([H])(CCC(N)=O)NC(=O)[C@]1([H])CCCN1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C27H38N6O7/c1-16(30-25(37)19(11-12-22(28)34)31-24(36)18-9-5-13-29-18)23(35)32-20(15-17-7-3-2-4-8-17)26(38)33-14-6-10-21(33)27(39)40/h2-4,7-8,16,18-21,29H,5-6,9-15H2,1H3,(H2,28,34)(H,30,37)(H,31,36)(H,32,35)(H,39,40)/t16-,18-,19-,20-,21-/m0/s1 InChIKey=CURUUJXNBGJESF-MQBSTWLZSA-N
Evidence 2 Activity

Activity

EC50
Antihypertensive
300.00 µM
ACE inhibitor
ah

Source & Reference

AHTPDB
Kohmura M., Nio N., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptide fragments of various beta-caseins. Agric.Biol.Chem. 54(4),1101-1102(1990)
1990
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
5
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](C)(NC(=O)[C@]([H])(CCC(N)=O)NC(=O)[C@]1([H])CCCN1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C27H38N6O7/c1-16(30-25(37)19(11-12-22(28)34)31-24(36)18-9-5-13-29-18)23(35)32-20(15-17-7-3-2-4-8-17)26(38)33-14-6-10-21(33)27(39)40/h2-4,7-8,16,18-21,29H,5-6,9-15H2,1H3,(H2,28,34)(H,30,37)(H,31,36)(H,32,35)(H,39,40)/t16-,18-,19-,20-,21-/m0/s1 InChIKey=CURUUJXNBGJESF-MQBSTWLZSA-N
Additional Detail Fields 1 fields
5