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Peptide record

TPDB47943

ACE inhibitor from alphas2-CN (189-192) ACE inhibitors Antihypertensive Neuropeptide standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB47943
ACE inhibitor from alphas2-CN (189-192)
ACE inhibitors Antihypertensive Neuropeptide
Cardiometabolic peptides Neuroactive peptides
Peptipedia AHTPDB AHTpin
standard
No
A 5-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Neuropeptide) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
AMKPW
Physicochemical Analysis
C30H45N7O6S1
RNDCEQGHILFSTYV
AKMPW
631.79
10.10
1
0
3
+1
-0.81
-0.540
20.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5500
870.54
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
1
K
1
M
0
F
1
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 1 M: 1 F: 0 P: 1 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
5
C30H45N7O6S1
631.79
10.10
+1
-0.81
-0.540
631.7859
631.3142
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
580.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Maeno M., Yamamoto N., Takano T.
Identification of an antihypertensive peptide from casein hydrolysate produced by a proteinase from Lactobacillus helveticus CP790. J. Dairy Sci., 79, 1316-1321, 1996
1996
book

Other

5
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](C)(N)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(CCCCN)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CC1=CNC2=C1C=CC=C2)C(O)=O InChI=1S/C30H45N7O6S/c1-18(32)26(38)34-22(12-15-44-2)27(39)35-23(10-5-6-13-31)29(41)37-14-7-11-25(37)28(40)36-24(30(42)43)16-19-17-33-21-9-4-3-8-20(19)21/h3-4,8-9,17-18,22-25,33H,5-7,10-16,31-32H2,1-2H3,(H,34,38)(H,35,39)(H,36,40)(H,42,43)/t18-,22-,23-,24-,25-/m0/s1 InChIKey=KSMJCDIEVLJDRV-WCJQXVFBSA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
580.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Maeno M., Yamamoto N., Takano T.
Identification of an antihypertensive peptide from casein hydrolysate produced by a proteinase from Lactobacillus helveticus CP790. J. Dairy Sci., 79, 1316-1321, 1996
1996
book

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
5
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](C)(N)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(CCCCN)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CC1=CNC2=C1C=CC=C2)C(O)=O InChI=1S/C30H45N7O6S/c1-18(32)26(38)34-22(12-15-44-2)27(39)35-23(10-5-6-13-31)29(41)37-14-7-11-25(37)28(40)36-24(30(42)43)16-19-17-33-21-9-4-3-8-20(19)21/h3-4,8-9,17-18,22-25,33H,5-7,10-16,31-32H2,1-2H3,(H,34,38)(H,35,39)(H,36,40)(H,42,43)/t18-,22-,23-,24-,25-/m0/s1 InChIKey=KSMJCDIEVLJDRV-WCJQXVFBSA-N
Additional Detail Fields 1 fields
5