Back to search

Peptide record

TPDB47942

ACE inhibitor (from bovine alphas1-CN) ACE inhibitors Antihypertensive standard
5 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB47942
ACE inhibitor (from bovine alphas1-CN)
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 5-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
FFVAP
Physicochemical Analysis
C31H41N5O6
RNDCEQGHILKMSTWY
F
579.70
6.02
0
0
4
-0
-1.91
2.000
78.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
2
F
1
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 2 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
5
C31H41N5O6
579.70
6.02
-0
-1.91
2.000
579.6855
579.3047
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
6.00 µM
Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Maruyama S., Nakagomi K., Tomizuka N., Suzuki H.
Angiotensin I-converting enzyme inhibitor derived from an enzymatic hydrolysate of casein. Isolation and bradykinin-potentiating activity on the uterus. Agric. Biol. Chem., 49, 1405-1409 (1985)
1985
Journal

Other

5
BIOPEP-UWM database of bioactive peptides SMILES: [C@H](N)(CC1=CC=CC=C1)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N3CCC[C@H]3C(O)=O InChI=1S/C31H41N5O6/c1-19(2)26(29(39)33-20(3)30(40)36-16-10-15-25(36)31(41)42)35-28(38)24(18-22-13-8-5-9-14-22)34-27(37)23(32)17-21-11-6-4-7-12-21/h4-9,11-14,19-20,23-26H,10,15-18,32H2,1-3H3,(H,33,39)(H,34,37)(H,35,38)(H,41,42)/t20-,23-,24-,25-,26-/m0/s1 InChIKey=VFERDGRYIBXYRG-REVLRCOSSA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
6.00 µM
Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Maruyama S., Nakagomi K., Tomizuka N., Suzuki H.
Angiotensin I-converting enzyme inhibitor derived from an enzymatic hydrolysate of casein. Isolation and bradykinin-potentiating activity on the uterus. Agric. Biol. Chem., 49, 1405-1409 (1985)
1985
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
5
BIOPEP-UWM database of bioactive peptides SMILES: [C@H](N)(CC1=CC=CC=C1)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N3CCC[C@H]3C(O)=O InChI=1S/C31H41N5O6/c1-19(2)26(29(39)33-20(3)30(40)36-16-10-15-25(36)31(41)42)35-28(38)24(18-22-13-8-5-9-14-22)34-27(37)23(32)17-21-11-6-4-7-12-21/h4-9,11-14,19-20,23-26H,10,15-18,32H2,1-3H3,(H,33,39)(H,34,37)(H,35,38)(H,41,42)/t20-,23-,24-,25-,26-/m0/s1 InChIKey=VFERDGRYIBXYRG-REVLRCOSSA-N
Additional Detail Fields 1 fields
5