TPDB

3D PDB MODEL

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TPDB ID TPDB47940

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 5-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.

Sequence

NLHLP

FASTA

>TPDB47940|ACE inhibitors;Antihypertensive|length=5
NLHLP

Formula C27H44N8O7

Absent Amino Acids ARDCEQGIKMFSTWYV

Common Amino Acids L

Mass 592.70

PI 7.85

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 2

Net Charge +0

Boman Index 0.71

Hydrophobicity -0.140

Aliphatic Index 156.00

Half Life

Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

0

A

0

R

1

N

0

D

0

C

0

E

0

Q

0

G

1

H

0

I

2

L

0

K

0

M

0

F

1

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 2 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

5

Formula

C27H44N8O7

Mass

592.70

PI

7.85

Net Charge

+0

Boman Index

0.71

Hydrophobicity

-0.140

Chemical_Mass

592.6859

Monoisotopic_Mass

592.3323

Evidence 1 Activity

Activity

Activity Endpoint EC50

Detail Source Activity ACE inhibitors

Activity Measurement 420.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.

Title

Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114, (1989)

Year 1989

Literature Source Journal

Other

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(N)=O)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(Cc1cnc[nH]1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C27H44N8O7/c1-14(2)8-18(32-23(37)17(28)11-22(29)36)24(38)33-19(10-16-12-30-13-31-16)25(39)34-20(9-15(3)4)26(40)35-7-5-6-21(35)27(41)42/h12-15,17-21H,5-11,28H2,1-4H3,(H2,29,36)(H,30,31)(H,32,37)(H,33,38)(H,34,39)(H,41,42)/t17-,18-,19-,20-,21-/m0/s1 InChIKey: LQUWIODWFHYVGU-SXYSDOLCSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001

Evidence 2 Activity

Activity

Activity Endpoint EC50

Detail Source Activity Antihypertensive

Activity Measurement 420.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.

Title

Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114, (1989)

Year 1989

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(N)=O)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(Cc1cnc[nH]1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C27H44N8O7/c1-14(2)8-18(32-23(37)17(28)11-22(29)36)24(38)33-19(10-16-12-30-13-31-16)25(39)34-20(9-15(3)4)26(40)35-7-5-6-21(35)27(41)42/h12-15,17-21H,5-11,28H2,1-4H3,(H2,29,36)(H,30,31)(H,32,37)(H,33,38)(H,34,39)(H,41,42)/t17-,18-,19-,20-,21-/m0/s1 InChIKey: LQUWIODWFHYVGU-SXYSDOLCSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001

Number_of_Residues

5