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Peptide record

TPDB47939

ACE inhibitor ACE inhibitors Antihypertensive standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB47939
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 5-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
PQPIP
Physicochemical Analysis
C26H42N6O7
ARNDCEGHLKMFSTWYV
P
550.66
6.02
0
0
1
-0
1.62
-0.760
78.00
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
0
0.00
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
1
I
0
L
0
K
0
M
0
F
3
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 3 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
5
C26H42N6O7
550.66
6.02
-0
1.62
-0.760
550.6460
550.3105
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
340.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

5
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](CCC(N)=O)(NC(=O)[C@]1([H])CCCN1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C26H42N6O7/c1-3-15(2)21(25(37)32-14-6-9-19(32)26(38)39)30-23(35)18-8-5-13-31(18)24(36)17(10-11-20(27)33)29-22(34)16-7-4-12-28-16/h15-19,21,28H,3-14H2,1-2H3,(H2,27,33)(H,29,34)(H,30,35)(H,38,39)/t15-,16-,17-,18-,19-,21-/m0/s1 InChIKey: MHFRWPJZAGBTQJ-WVBSATCKSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
340.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
5
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](CCC(N)=O)(NC(=O)[C@]1([H])CCCN1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C26H42N6O7/c1-3-15(2)21(25(37)32-14-6-9-19(32)26(38)39)30-23(35)18-8-5-13-31(18)24(36)17(10-11-20(27)33)29-22(34)16-7-4-12-28-16/h15-19,21,28H,3-14H2,1-2H3,(H2,27,33)(H,29,34)(H,30,35)(H,38,39)/t15-,16-,17-,18-,19-,21-/m0/s1 InChIKey: MHFRWPJZAGBTQJ-WVBSATCKSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
5