TPDB

3D PDB MODEL

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TPDB ID TPDB47933

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 5-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.

Sequence

GRVMP

FASTA

>TPDB47933|ACE inhibitors;Antihypertensive|length=5
GRVMP

Formula C23H42N8O6S1

Absent Amino Acids ANDCEQHILKFSTWY

Common Amino Acids RGMPV

Mass 558.70

PI 11.05

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 2

Net Charge +1

Boman Index 1.11

Hydrophobicity -0.080

Aliphatic Index 58.00

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

1

R

0

N

0

D

0

C

0

E

0

Q

1

G

0

H

0

I

0

L

0

K

1

M

0

F

1

P

0

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 1 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 1

Length

5

Formula

C23H42N8O6S1

Mass

558.70

PI

11.05

Net Charge

+1

Boman Index

1.11

Hydrophobicity

-0.080

Chemical_Mass

558.6940

Monoisotopic_Mass

558.2939

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 250.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.

Title

Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem. 53 (8), 2107-2114 (1989)

Year 1989

Literature Source Journal

Other

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides: SMILES: NCC(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCSC)C(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C23H42N8O6S/c1-13(2)18(30-19(33)14(28-17(32)12-24)6-4-9-27-23(25)26)20(34)29-15(8-11-38-3)21(35)31-10-5-7-16(31)22(36)37/h13-16,18H,4-12,24H2,1-3H3,(H,28,32)(H,29,34)(H,30,33)(H,36,37)(H4,25,26,27)/t14-,15-,16-,18-/m0/s1 InChIKey: ADGGEQGHEZVHRJ-OVWQWFNUSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID M02-001

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 250.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.

Title

Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem. 53 (8), 2107-2114 (1989)

Year 1989

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides: SMILES: NCC(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCSC)C(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C23H42N8O6S/c1-13(2)18(30-19(33)14(28-17(32)12-24)6-4-9-27-23(25)26)20(34)29-15(8-11-38-3)21(35)31-10-5-7-16(31)22(36)37/h13-16,18H,4-12,24H2,1-3H3,(H,28,32)(H,29,34)(H,30,33)(H,36,37)(H4,25,26,27)/t14-,15-,16-,18-/m0/s1 InChIKey: ADGGEQGHEZVHRJ-OVWQWFNUSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID M02-001

Number_of_Residues

5