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Peptide record

TPDB47930

ACE inhibitor ACE inhibitors Antihypertensive standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB47930
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
FermFooDB pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 5-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from FermFooDB, pep-lab, Peptipedia, and other sources, with an available 3D structural model.
Sequence
DKIHP
Physicochemical Analysis
C27H44N8O8
ARNCEQGLMFSTWYV
DHIKP
608.70
7.81
2
1
1
+0
3.32
-1.540
78.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
1
D
0
C
0
E
0
Q
0
G
1
H
1
I
0
L
1
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 1 L: 0 K: 1 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
5
C27H44N8O8
608.70
7.81
+0
3.32
-1.540
608.6853
608.3272
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
0.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

FermFooDB
Gómez-Ruiz J. A., Recio I., Belloque J.
ACE-inhibitory activity and structural properties of peptide Asp-Lys-Ile-His-Pro [beta-CN f (47-51)]. Study of the peptide forms synthesized by different methods. J. Agric. Food Chem., 2004, 52, 6315-6319
2004
Journal

Other

5
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(O)=O)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@]([H])(C(=O)N[C@@H](CC1=CNC=N1)C(=O)N1CCC[C@@]1([H])C(O)=O)[C@@]([H])(C)CC InChI=1S/C27H44N8O8/c1-3-15(2)22(34-24(39)18(7-4-5-9-28)32-23(38)17(29)12-21(36)37)25(40)33-19(11-16-13-30-14-31-16)26(41)35-10-6-8-20(35)27(42)43/h13-15,17-20,22H,3-12,28-29H2,1-2H3,(H,30,31)(H,32,38)(H,33,40)(H,34,39)(H,36,37)(H,42,43)/t15-,17-,18-,19-,20-,22-/m0/s1 InChIKey: IVARWCKCCBGZOD-VWTBICAHSA-N Another publication concerning peptide: Gómez-Ruiz J.A., Taborda G., Amigo L., Recio I., Ramos M., 2006, Identification of ACE-inhibitory peptides in different Spanish cheeses by tandem mass spectrometry. European Food Research Technology, 223, 595–601 Another IC50 value: 113.1 M according to Gómez-Ruiz et al. 2006
Evidence 2 Activity

Activity

IC50
Antihypertensive
0.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB FermFooDB
Gómez-Ruiz J. A., Recio I., Belloque J.
ACE-inhibitory activity and structural properties of peptide Asp-Lys-Ile-His-Pro [beta-CN f (47-51)]. Study of the peptide forms synthesized by different methods. J. Agric. Food Chem., 2004, 52, 6315-6319
2004
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
5
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(O)=O)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@]([H])(C(=O)N[C@@H](CC1=CNC=N1)C(=O)N1CCC[C@@]1([H])C(O)=O)[C@@]([H])(C)CC InChI=1S/C27H44N8O8/c1-3-15(2)22(34-24(39)18(7-4-5-9-28)32-23(38)17(29)12-21(36)37)25(40)33-19(11-16-13-30-14-31-16)26(41)35-10-6-8-20(35)27(42)43/h13-15,17-20,22H,3-12,28-29H2,1-2H3,(H,30,31)(H,32,38)(H,33,40)(H,34,39)(H,36,37)(H,42,43)/t15-,17-,18-,19-,20-,22-/m0/s1 InChIKey: IVARWCKCCBGZOD-VWTBICAHSA-N Another publication concerning peptide: Gómez-Ruiz J.A., Taborda G., Amigo L., Recio I., Ramos M., 2006, Identification of ACE-inhibitory peptides in different Spanish cheeses by tandem mass spectrometry. European Food Research Technology, 223, 595–601 Another IC50 value: 113.1 M according to Gómez-Ruiz et al. 2006
Additional Detail Fields 1 fields
5