TPDB

3D PDB MODEL

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TPDB ID TPDB47929

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 5-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.

Sequence

PVPQP

FASTA

>TPDB47929|ACE inhibitors;Antihypertensive|length=5
PVPQP

Formula C25H40N6O7

Absent Amino Acids ARNDCEGHILKMFSTWY

Common Amino Acids P

Mass 536.63

PI 6.02

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 1

Net Charge -0

Boman Index 2.00

Hydrophobicity -0.820

Aliphatic Index 58.00

Half Life

Mammalian: >20 hour Yeast: >20 hour E.coli: ?

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

0

A

0

R

0

N

0

D

0

C

0

E

1

Q

0

G

0

H

0

I

0

L

0

K

0

M

0

F

3

P

0

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 3 S: 0 T: 0 W: 0 Y: 0 V: 1

Length

5

Formula

C25H40N6O7

Mass

536.63

PI

6.02

Net Charge

-0

Boman Index

2.00

Hydrophobicity

-0.820

Chemical_Mass

536.6195

Monoisotopic_Mass

536.2949

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 110.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.

Title

Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem. 53, 2107-2114 (1989)

Year 1989

Literature Source Journal

Other

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C25H40N6O7/c1-14(2)20(29-21(33)15-6-3-11-27-15)24(36)30-12-4-7-17(30)22(34)28-16(9-10-19(26)32)23(35)31-13-5-8-18(31)25(37)38/h14-18,20,27H,3-13H2,1-2H3,(H2,26,32)(H,28,34)(H,29,33)(H,37,38)/t15-,16-,17-,18-,20-/m0/s1 InChIKey: OGPXTYONFBARDV-VKESLTNKSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID M02-001

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 110.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.

Title

Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem. 53, 2107-2114 (1989)

Year 1989

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C25H40N6O7/c1-14(2)20(29-21(33)15-6-3-11-27-15)24(36)30-12-4-7-17(30)22(34)28-16(9-10-19(26)32)23(35)31-13-5-8-18(31)25(37)38/h14-18,20,27H,3-13H2,1-2H3,(H2,26,32)(H,28,34)(H,29,33)(H,37,38)/t15-,16-,17-,18-,20-/m0/s1 InChIKey: OGPXTYONFBARDV-VKESLTNKSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID M02-001

Number_of_Residues

5