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Peptide record

TPDB47928

ACE Inhibitor ACE inhibitors Antihypertensive standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB47928
ACE Inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB AHTpin
standard
No
A 5-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
VKAGF
Physicochemical Analysis
C25H40N6O6
RNDCEQHILMPSTWY
AGKFV
520.63
10.10
1
0
3
+1
-0.23
0.900
78.00
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
1
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 1 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
5
C25H40N6O6
520.63
10.10
+1
-0.23
0.900
520.6201
520.3000
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
83.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

NA
Ukeda H., Matsuda H., Osajima K., Matsufuji H., Matsui T., and Osajima Y.
Nippon Nogeikagaku Kaishi 66, 25-29
1992
Journal

Other

5
BIOPEP database of bioactive peptides SMILES: N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)O InChI=1S/C25H40N6O6/c1-15(2)21(27)24(35)31-18(11-7-8-12-26)23(34)29-16(3)22(33)28-14-20(32)30-19(25(36)37)13-17-9-5-4-6-10-17/h4-6,9-10,15-16,18-19,21H,7-8,11-14,26-27H2,1-3H3,(H,28,33)(H,29,34)(H,30,32)(H,31,35)(H,36,37)/t16-,18-,19-,21-/m0/s1 InCHIKey: DHWOFWYUMIHTRI-WBKMXMRLSA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
83.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Ukeda H., Matsuda H., Osajima K., Matsufuji H., Matsui T., and Osajima Y.
Nippon Nogeikagaku Kaishi 66, 25-29
1992
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
5
BIOPEP database of bioactive peptides SMILES: N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)O InChI=1S/C25H40N6O6/c1-15(2)21(27)24(35)31-18(11-7-8-12-26)23(34)29-16(3)22(33)28-14-20(32)30-19(25(36)37)13-17-9-5-4-6-10-17/h4-6,9-10,15-16,18-19,21H,7-8,11-14,26-27H2,1-3H3,(H,28,33)(H,29,34)(H,30,32)(H,31,35)(H,36,37)/t16-,18-,19-,21-/m0/s1 InCHIKey: DHWOFWYUMIHTRI-WBKMXMRLSA-N
Additional Detail Fields 1 fields
5