TPDB

3D PDB MODEL

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TPDB ID TPDB47927

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 5-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.

Sequence

IRAQQ

FASTA

>TPDB47927|ACE inhibitors;Antihypertensive|length=5
IRAQQ

Formula C25H46N10O8

Absent Amino Acids NDCEGHLKMFPSTWYV

Common Amino Acids Q

Mass 614.70

PI 11.05

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 2

Net Charge +1

Boman Index 1.49

Hydrophobicity -1.040

Aliphatic Index 98.00

Half Life

Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 2

number

1

A

1

R

0

N

0

D

0

C

0

E

2

Q

0

G

0

H

1

I

0

L

0

K

0

M

0

F

0

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

5

Formula

C25H46N10O8

Mass

614.70

PI

11.05

Net Charge

+1

Boman Index

1.49

Hydrophobicity

-1.040

Chemical_Mass

614.6931

Monoisotopic_Mass

614.3490

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 4.20 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Miyoshi S., Ishikawa H., Kaneko T., Fukui F., Tanaka H.

Title

Structure and activity of angiotensin-converting enzyme inhibitors in a-zein hydrolysate. Agric.Biol.Chem.55(5),1313-1318(1991)

Year 1991

Literature Source Journal

Other

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](C)(NC(=O)[C@]([H])(CCCNC(N)=N)NC(=O)[C@@]([H])(N)[C@@]([H])(C)CC)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CCC(N)=O)C(O)=O InChI=1S/C25H46N10O8/c1-4-12(2)19(28)23(41)34-14(6-5-11-31-25(29)30)21(39)32-13(3)20(38)33-15(7-9-17(26)36)22(40)35-16(24(42)43)8-10-18(27)37/h12-16,19H,4-11,28H2,1-3H3,(H2,26,36)(H2,27,37)(H,32,39)(H,33,38)(H,34,41)(H,35,40)(H,42,43)(H4,29,30,31)/t12-,13-,14-,15-,16-,19-/m0/s1 InChIKey=UYXULJMCSGYMBM-GGDDPFQJSA-N

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 4.20 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Miyoshi S., Ishikawa H., Kaneko T., Fukui F., Tanaka H.

Title

Structure and activity of angiotensin-converting enzyme inhibitors in a-zein hydrolysate. Agric.Biol.Chem.55(5),1313-1318(1991)

Year 1991

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](C)(NC(=O)[C@]([H])(CCCNC(N)=N)NC(=O)[C@@]([H])(N)[C@@]([H])(C)CC)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CCC(N)=O)C(O)=O InChI=1S/C25H46N10O8/c1-4-12(2)19(28)23(41)34-14(6-5-11-31-25(29)30)21(39)32-13(3)20(38)33-15(7-9-17(26)36)22(40)35-16(24(42)43)8-10-18(27)37/h12-16,19H,4-11,28H2,1-3H3,(H2,26,36)(H2,27,37)(H,32,39)(H,33,38)(H,34,41)(H,35,40)(H,42,43)(H4,29,30,31)/t12-,13-,14-,15-,16-,19-/m0/s1 InChIKey=UYXULJMCSGYMBM-GGDDPFQJSA-N

Number_of_Residues

5