Back to search

Peptide record

TPDB47926

ACE inhibitor from beta-CN ACE inhibitors Antihypertensive standard
5 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB47926
ACE inhibitor from beta-CN
ACE inhibitors Antihypertensive
Cardiometabolic peptides
pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 5-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
AVPYP
Physicochemical Analysis
C27H39N5O7
RNDCEQGHILKMFSTW
P
545.64
5.94
0
0
3
-0
-0.14
0.300
78.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
1490
273.08
1
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
2
P
0
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
5
C27H39N5O7
545.64
5.94
-0
-0.14
0.300
545.6263
545.2840
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
80.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Maruyama S., Mitachi H., Tanaka H., Tomizuka N., Suzuki H.
Studies on the active site and antihypertensive activity of angiotensin I-converting enzyme inhibitors derived from casein. Agric. Biol. Chem., 51, 1581-1586, 1987
1987
book

Other

5
AHTPDB: ID 1125, 2436, 3384, 4066, 5311, 5857, 6356 BindingDB: ID 50049842 BioPepDB: ID biopep00088 ChEMBL: ID CHEMBL3322124 ChemSpider: ID 58109278 EROP-Moscow: ID E14543 FeptideDB: ID 3371 MBPDB: peptide AVPYP PubChem: CID 71352622 SATPdb: ID satpdb25506 ZINC: ID ZINC000205301699
Evidence 2 Activity

Activity

IC50
Antihypertensive
80.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Maruyama S., Mitachi H., Tanaka H., Tomizuka N., Suzuki H.
Studies on the active site and antihypertensive activity of angiotensin I-converting enzyme inhibitors derived from casein. Agric. Biol. Chem., 51, 1581-1586, 1987
1987
book

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
5
AHTPDB: ID 1125, 2436, 3384, 4066, 5311, 5857, 6356 BindingDB: ID 50049842 BioPepDB: ID biopep00088 ChEMBL: ID CHEMBL3322124 ChemSpider: ID 58109278 EROP-Moscow: ID E14543 FeptideDB: ID 3371 MBPDB: peptide AVPYP PubChem: CID 71352622 SATPdb: ID satpdb25506 ZINC: ID ZINC000205301699
Additional Detail Fields 1 fields
5