TPDB

3D PDB MODEL

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TPDB ID TPDB47923

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 5-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.

Sequence

PSFQP

FASTA

>TPDB47923|ACE inhibitors;Antihypertensive|length=5
PSFQP

Formula C27H38N6O8

Absent Amino Acids ARNDCEGHILKMTWYV

Common Amino Acids P

Mass 574.63

PI 6.02

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 1

Net Charge -0

Boman Index 0.48

Hydrophobicity -0.940

Aliphatic Index 0.00

Half Life

Mammalian: >20 hour Yeast: >20 hour E.coli: ?

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 2

number

0

A

0

R

0

N

0

D

0

C

0

E

1

Q

0

G

0

H

0

I

0

L

0

K

0

M

1

F

2

P

1

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 2 S: 1 T: 0 W: 0 Y: 0 V: 0

Length

5

Formula

C27H38N6O8

Mass

574.63

PI

6.02

Net Charge

-0

Boman Index

0.48

Hydrophobicity

-0.940

Chemical_Mass

574.6245

Monoisotopic_Mass

574.2742

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 73.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.

Title

Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)

Year 1989

Literature Source Journal

Other

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C27H38N6O8/c28-22(35)11-10-18(26(39)33-13-5-9-21(33)27(40)41)30-24(37)19(14-16-6-2-1-3-7-16)31-25(38)20(15-34)32-23(36)17-8-4-12-29-17/h1-3,6-7,17-21,29,34H,4-5,8-15H2,(H2,28,35)(H,30,37)(H,31,38)(H,32,36)(H,40,41)/t17-,18-,19-,20-,21-/m0/s1 InChIKey: XCNLWSOXJYOVND-SXYSDOLCSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 73.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.

Title

Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)

Year 1989

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C27H38N6O8/c28-22(35)11-10-18(26(39)33-13-5-9-21(33)27(40)41)30-24(37)19(14-16-6-2-1-3-7-16)31-25(38)20(15-34)32-23(36)17-8-4-12-29-17/h1-3,6-7,17-21,29,34H,4-5,8-15H2,(H2,28,35)(H,30,37)(H,31,38)(H,32,36)(H,40,41)/t17-,18-,19-,20-,21-/m0/s1 InChIKey: XCNLWSOXJYOVND-SXYSDOLCSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001

Number_of_Residues

5