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Peptide record

TPDB47922

ACE inhibitor ACE inhibitors Antihypertensive standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB47922
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB AHTpin
standard
No
A 5-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
HQIYP
Physicochemical Analysis
C31H44N8O8
ARNDCEGLKMFSTWV
QHIPY
656.74
7.77
1
0
2
+0
0.74
-1.020
78.00
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
1490
226.88
2
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
1
Q
0
G
1
H
1
I
0
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 1 I: 1 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
5
C31H44N8O8
656.74
7.77
+0
0.74
-1.020
656.7281
656.3272
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
110.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

5
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1cnc[nH]1)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C31H44N8O8/c1-3-17(2)26(38-28(43)22(10-11-25(33)41)36-27(42)21(32)14-19-15-34-16-35-19)29(44)37-23(13-18-6-8-20(40)9-7-18)30(45)39-12-4-5-24(39)31(46)47/h6-9,15-17,21-24,26,40H,3-5,10-14,32H2,1-2H3,(H2,33,41)(H,34,35)(H,36,42)(H,37,44)(H,38,43)(H,46,47)/t17-,21-,22-,23-,24-,26-/m0/s1 InChIKey: WGNMLOKJLJZPFR-CIGSZAAZSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
110.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
5
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1cnc[nH]1)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C31H44N8O8/c1-3-17(2)26(38-28(43)22(10-11-25(33)41)36-27(42)21(32)14-19-15-34-16-35-19)29(44)37-23(13-18-6-8-20(40)9-7-18)30(45)39-12-4-5-24(39)31(46)47/h6-9,15-17,21-24,26,40H,3-5,10-14,32H2,1-2H3,(H2,33,41)(H,34,35)(H,36,42)(H,37,44)(H,38,43)(H,46,47)/t17-,21-,22-,23-,24-,26-/m0/s1 InChIKey: WGNMLOKJLJZPFR-CIGSZAAZSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
5