TPDB

3D PDB MODEL

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TPDB ID TPDB47921

Peptide_Name

human beta-casein fr. 57-61

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 5-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.

Sequence

SLVYP

FASTA

>TPDB47921|ACE inhibitors;Antihypertensive|length=5
SLVYP

Formula C28H43N5O8

Absent Amino Acids ARNDCEQGHIKMFTW

Common Amino Acids LPSYV

Mass 577.68

PI 5.94

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 3

Net Charge -0

Boman Index -0.85

Hydrophobicity 0.860

Aliphatic Index 136.00

Half Life

Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 1490

Absorbance 280nm 257.93

Polar Residues 2

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

1

L

0

K

0

M

0

F

1

P

1

S

0

T

0

W

1

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 1 V: 1

Length

5

Formula

C28H43N5O8

Mass

577.68

PI

5.94

Net Charge

-0

Boman Index

-0.85

Hydrophobicity

0.860

Chemical_Mass

577.6680

Monoisotopic_Mass

577.3101

Evidence 1 Activity

Activity

Activity Endpoint EC50

Detail Source Activity ACE inhibitors

Activity Measurement 41.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Kohmura M., Nio N., Ariyoshi Y.

Title

Inhibition of angiotensin-converting enzyme by synthetic peptide fragments of various beta-caseins. Agric. Biol. Chem., 54, 1101-1102, 1990

Year 1990

Literature Source Journal

Other

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C28H43N5O8/c1-15(2)12-20(30-24(36)19(29)14-34)25(37)32-23(16(3)4)26(38)31-21(13-17-7-9-18(35)10-8-17)27(39)33-11-5-6-22(33)28(40)41/h7-10,15-16,19-23,34-35H,5-6,11-14,29H2,1-4H3,(H,30,36)(H,31,38)(H,32,37)(H,40,41)/t19-,20-,21-,22-,23-/m0/s1 InChIKey=TURVFKAEKRZGOB-VUBDRERZSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001

Evidence 2 Activity

Activity

Activity Endpoint EC50

Detail Source Activity Antihypertensive

Activity Measurement 41.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Kohmura M., Nio N., Ariyoshi Y.

Title

Inhibition of angiotensin-converting enzyme by synthetic peptide fragments of various beta-caseins. Agric. Biol. Chem., 54, 1101-1102, 1990

Year 1990

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C28H43N5O8/c1-15(2)12-20(30-24(36)19(29)14-34)25(37)32-23(16(3)4)26(38)31-21(13-17-7-9-18(35)10-8-17)27(39)33-11-5-6-22(33)28(40)41/h7-10,15-16,19-23,34-35H,5-6,11-14,29H2,1-4H3,(H,30,36)(H,31,38)(H,32,37)(H,40,41)/t19-,20-,21-,22-,23-/m0/s1 InChIKey=TURVFKAEKRZGOB-VUBDRERZSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001

Number_of_Residues

5