TPDB

3D PDB MODEL

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TPDB ID TPDB47918

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 5-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.

Sequence

VLPIP

FASTA

>TPDB47918|ACE inhibitors;Antihypertensive|length=5
VLPIP

Formula C27H47N5O6

Absent Amino Acids ARNDCEQGHKMFSTWY

Common Amino Acids P

Mass 537.70

PI 6.02

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 3

Net Charge -0

Boman Index 0.10

Hydrophobicity 1.860

Aliphatic Index 214.00

Half Life

Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

1

I

1

L

0

K

0

M

0

F

2

P

0

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 1

Length

5

Formula

C27H47N5O6

Mass

537.70

PI

6.02

Net Charge

-0

Boman Index

0.10

Hydrophobicity

1.860

Chemical_Mass

537.6901

Monoisotopic_Mass

537.3515

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 31.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.

Title

Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)

Year 1989

Literature Source Journal

Other

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C27H47N5O6/c1-7-17(6)22(26(36)32-13-9-11-20(32)27(37)38)30-23(33)19-10-8-12-31(19)25(35)18(14-15(2)3)29-24(34)21(28)16(4)5/h15-22H,7-14,28H2,1-6H3,(H,29,34)(H,30,33)(H,37,38)/t17-,18-,19-,20-,21-,22-/m0/s1 InChIKey: BXEXRTQZWQNFIX-WLNPFYQQSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 31.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.

Title

Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)

Year 1989

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C27H47N5O6/c1-7-17(6)22(26(36)32-13-9-11-20(32)27(37)38)30-23(33)19-10-8-12-31(19)25(35)18(14-15(2)3)29-24(34)21(28)16(4)5/h15-22H,7-14,28H2,1-6H3,(H,29,34)(H,30,33)(H,37,38)/t17-,18-,19-,20-,21-,22-/m0/s1 InChIKey: BXEXRTQZWQNFIX-WLNPFYQQSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001

Number_of_Residues

5