TPDB

3D PDB MODEL

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TPDB ID TPDB47911

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 5-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.

Sequence

VHIPP

FASTA

>TPDB47911|ACE inhibitors;Antihypertensive|length=5
VHIPP

Formula C27H43N7O6

Absent Amino Acids ARNDCEQGLKMFSTWY

Common Amino Acids P

Mass 561.68

PI 7.85

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 2

Net Charge +0

Boman Index 1.62

Hydrophobicity 0.460

Aliphatic Index 136.00

Half Life

Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

1

H

1

I

0

L

0

K

0

M

0

F

2

P

0

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 1 L: 0 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 1

Length

5

Formula

C27H43N7O6

Mass

561.68

PI

7.85

Net Charge

+0

Boman Index

1.62

Hydrophobicity

0.460

Chemical_Mass

561.6719

Monoisotopic_Mass

561.3265

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 10.00 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Maruyama S., Miyoshi S., Kaneko T., Tanaka H.

Title

Angotensin I-converting enzyme inhibitory activities of synthetic peptides related to the tandem repeated sequence of a maize endosperm protein.Agric.Biol.Chem.53(4),1077-1081(1989)

Year 1989

Literature Source Journal

Other

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](C)(CC)[C@]([H])(NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@]([H])(N)C(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C27H43N7O6/c1-5-16(4)22(26(38)33-10-6-8-19(33)25(37)34-11-7-9-20(34)27(39)40)32-23(35)18(12-17-13-29-14-30-17)31-24(36)21(28)15(2)3/h13-16,18-22H,5-12,28H2,1-4H3,(H,29,30)(H,31,36)(H,32,35)(H,39,40)/t16-,18-,19-,20-,21-,22-/m0/s1 InChIKey=SGWAQTSBEVKKPC-PLOPKLDOSA-N

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 10.00 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Maruyama S., Miyoshi S., Kaneko T., Tanaka H.

Title

Angotensin I-converting enzyme inhibitory activities of synthetic peptides related to the tandem repeated sequence of a maize endosperm protein.Agric.Biol.Chem.53(4),1077-1081(1989)

Year 1989

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](C)(CC)[C@]([H])(NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@]([H])(N)C(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C27H43N7O6/c1-5-16(4)22(26(38)33-10-6-8-19(33)25(37)34-11-7-9-20(34)27(39)40)32-23(35)18(12-17-13-29-14-30-17)31-24(36)21(28)15(2)3/h13-16,18-22H,5-12,28H2,1-4H3,(H,29,30)(H,31,36)(H,32,35)(H,39,40)/t16-,18-,19-,20-,21-,22-/m0/s1 InChIKey=SGWAQTSBEVKKPC-PLOPKLDOSA-N

Number_of_Residues

5