TPDB

3D PDB MODEL

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TPDB ID TPDB47906

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 5-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.

Sequence

LYPVK

FASTA

>TPDB47906|ACE inhibitors;Antihypertensive|length=5
LYPVK

Formula C31H50N6O7

Absent Amino Acids ARNDCEQGHIMFSTW

Common Amino Acids LKPYV

Mass 618.77

PI 9.74

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 3

Net Charge +1

Boman Index 0.01

Hydrophobicity 0.240

Aliphatic Index 136.00

Half Life

Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 1490

Absorbance 280nm 240.80

Polar Residues 1

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

1

L

1

K

0

M

0

F

1

P

0

S

0

T

0

W

1

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 1 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 1

Length

5

Formula

C31H50N6O7

Mass

618.77

PI

9.74

Net Charge

+1

Boman Index

0.01

Hydrophobicity

0.240

Chemical_Mass

618.7627

Monoisotopic_Mass

618.3729

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 4.50 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Maruyama S., Miyoshi S., Tanaka H.

Title Angiotensin I-converting enzyme inhibitors derived from ficus carica.Agric.Biol.Chem.53(10),2763-2767(1989)

Year 1989

Literature Source Journal

Other

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCCN)C(O)=O InChI=1S/C31H50N6O7/c1-18(2)16-22(33)27(39)35-24(17-20-10-12-21(38)13-11-20)30(42)37-15-7-9-25(37)28(40)36-26(19(3)4)29(41)34-23(31(43)44)8-5-6-14-32/h10-13,18-19,22-26,38H,5-9,14-17,32-33H2,1-4H3,(H,34,41)(H,35,39)(H,36,40)(H,43,44)/t22-,23-,24-,25-,26-/m0/s1 InChIKey=RVGOPVDNLHRSFF-LROMGURASA-N

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 4.50 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Maruyama S., Miyoshi S., Tanaka H.

Title Angiotensin I-converting enzyme inhibitors derived from ficus carica.Agric.Biol.Chem.53(10),2763-2767(1989)

Year 1989

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCCN)C(O)=O InChI=1S/C31H50N6O7/c1-18(2)16-22(33)27(39)35-24(17-20-10-12-21(38)13-11-20)30(42)37-15-7-9-25(37)28(40)36-26(19(3)4)29(41)34-23(31(43)44)8-5-6-14-32/h10-13,18-19,22-26,38H,5-9,14-17,32-33H2,1-4H3,(H,34,41)(H,35,39)(H,36,40)(H,43,44)/t22-,23-,24-,25-,26-/m0/s1 InChIKey=RVGOPVDNLHRSFF-LROMGURASA-N

Number_of_Residues

5