TPDB

3D PDB MODEL

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TPDB ID TPDB47905

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 5-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.

Sequence

VHLAP

FASTA

>TPDB47905|ACE inhibitors;Antihypertensive|length=5
VHLAP

Formula C25H41N7O6

Absent Amino Acids RNDCEQGIKMFSTWY

Common Amino Acids AHLPV

Mass 535.64

PI 7.85

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 3

Net Charge +0

Boman Index 0.75

Hydrophobicity 1.000

Aliphatic Index 156.00

Half Life

Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

1

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

1

H

0

I

1

L

0

K

0

M

0

F

1

P

0

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 1

Length

5

Formula

C25H41N7O6

Mass

535.64

PI

7.85

Net Charge

+0

Boman Index

0.75

Hydrophobicity

1.000

Chemical_Mass

535.6347

Monoisotopic_Mass

535.3109

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 4.50 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Maruyama S., Miyoshi S., Kaneko T., Tanaka H.

Title

Angotensin I-converting enzyme inhibitory activities of synthetic peptides related to the tandem repeated sequence of a maize endosperm protein.Agric.Biol.Chem.53(4),1077-1081(1989)

Year 1989

Literature Source Journal

Other

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](C)(NC(=O)[C@]([H])(CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@]([H])(N)C(C)C)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C25H41N7O6/c1-13(2)9-17(21(33)29-15(5)24(36)32-8-6-7-19(32)25(37)38)30-22(34)18(10-16-11-27-12-28-16)31-23(35)20(26)14(3)4/h11-15,17-20H,6-10,26H2,1-5H3,(H,27,28)(H,29,33)(H,30,34)(H,31,35)(H,37,38)/t15-,17-,18-,19-,20-/m0/s1 InChIKey=LTHJWGJDQGQTFZ-JBDAPHQKSA-N

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 4.50 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Maruyama S., Miyoshi S., Kaneko T., Tanaka H.

Title

Angotensin I-converting enzyme inhibitory activities of synthetic peptides related to the tandem repeated sequence of a maize endosperm protein.Agric.Biol.Chem.53(4),1077-1081(1989)

Year 1989

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](C)(NC(=O)[C@]([H])(CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@]([H])(N)C(C)C)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C25H41N7O6/c1-13(2)9-17(21(33)29-15(5)24(36)32-8-6-7-19(32)25(37)38)30-22(34)18(10-16-11-27-12-28-16)31-23(35)20(26)14(3)4/h11-15,17-20H,6-10,26H2,1-5H3,(H,27,28)(H,29,33)(H,30,34)(H,31,35)(H,37,38)/t15-,17-,18-,19-,20-/m0/s1 InChIKey=LTHJWGJDQGQTFZ-JBDAPHQKSA-N

Number_of_Residues

5