TPDB

3D PDB MODEL

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TPDB ID TPDB47904

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 5-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.

Sequence

PLIYP

FASTA

>TPDB47904|ACE inhibitors;Antihypertensive|length=5
PLIYP

Formula C31H47N5O7

Absent Amino Acids ARNDCEQGHKMFSTWV

Common Amino Acids P

Mass 601.74

PI 5.94

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 3

Net Charge -0

Boman Index -0.91

Hydrophobicity 0.760

Aliphatic Index 156.00

Half Life

Mammalian: >20 hour Yeast: >20 hour E.coli: ?

Extinction Coefficient Cystines 1490

Absorbance 280nm 247.61

Polar Residues 1

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

1

I

1

L

0

K

0

M

0

F

2

P

0

S

0

T

0

W

1

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 1 V: 0

Length

5

Formula

C31H47N5O7

Mass

601.74

PI

5.94

Net Charge

-0

Boman Index

-0.91

Hydrophobicity

0.760

Chemical_Mass

601.7323

Monoisotopic_Mass

601.3464

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 4.40 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.

Title

Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)

Year 1989

Literature Source Journal

Other

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](CC(C)C)(NC(=O)[C@]1([H])CCCN1)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C31H47N5O7/c1-5-19(4)26(35-28(39)23(16-18(2)3)33-27(38)22-8-6-14-32-22)29(40)34-24(17-20-10-12-21(37)13-11-20)30(41)36-15-7-9-25(36)31(42)43/h10-13,18-19,22-26,32,37H,5-9,14-17H2,1-4H3,(H,33,38)(H,34,40)(H,35,39)(H,42,43)/t19-,22-,23-,24-,25-,26-/m0/s1 InChIKey: NIKFPOGUEGZYAR-KTHKBMNISA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 4.40 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.

Title

Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)

Year 1989

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](CC(C)C)(NC(=O)[C@]1([H])CCCN1)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C31H47N5O7/c1-5-19(4)26(35-28(39)23(16-18(2)3)33-27(38)22-8-6-14-32-22)29(40)34-24(17-20-10-12-21(37)13-11-20)30(41)36-15-7-9-25(36)31(42)43/h10-13,18-19,22-26,32,37H,5-9,14-17H2,1-4H3,(H,33,38)(H,34,40)(H,35,39)(H,42,43)/t19-,22-,23-,24-,25-,26-/m0/s1 InChIKey: NIKFPOGUEGZYAR-KTHKBMNISA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001

Number_of_Residues

5