TPDB

3D PDB MODEL

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TPDB ID TPDB47903

Peptide_Name

ACE Inhibitor

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 5-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.

Sequence

DIGYY

FASTA

>TPDB47903|ACE inhibitors;Antihypertensive|length=5
DIGYY

Formula C30H39N5O10

Absent Amino Acids ARNCEQHLKMFPSTWV

Common Amino Acids Y

Mass 629.67

PI 3.10

Basic Residues 0

Acidic Residues 1

Hydrophobic Residues 3

Net Charge -1

Boman Index -0.95

Hydrophobicity -0.400

Aliphatic Index 78.00

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour

Extinction Coefficient Cystines 2980

Absorbance 280nm 473.27

Polar Residues 2

number

0

A

0

R

0

N

1

D

0

C

0

E

0

Q

1

G

0

H

1

I

0

L

0

K

0

M

0

F

0

P

0

S

0

T

0

W

2

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 2 V: 0

Length

5

Formula

C30H39N5O10

Mass

629.67

PI

3.10

Net Charge

-1

Boman Index

-0.95

Hydrophobicity

-0.400

Chemical_Mass

629.6566

Monoisotopic_Mass

629.2687

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 3.39 µM

Function Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Matsui T., Li C.-H., Osajima Y.

Title

Preparation and characterization of novel bioactive peptides responsible for angiotensin I-converting enzyme inhibition from wheat germ. J. Peptide Sci., 5, 289-297, 1999

Year 1999

Literature Source Journal

Other

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC(=O)O)C(=O)N[C@@H]([C@H](CC)C)C(=O)NCC(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)O InChI=1S/C30H39N5O10/c1-3-16(2)26(35-27(41)21(31)14-25(39)40)29(43)32-15-24(38)33-22(12-17-4-8-19(36)9-5-17)28(42)34-23(30(44)45)13-18-6-10-20(37)11-7-18/h4-11,16,21-23,26,36-37H,3,12-15,31H2,1-2H3,(H,32,43)(H,33,38)(H,34,42)(H,35,41)(H,39,40)(H,44,45)/t16-,21-,22-,23-,26-/m0/s1 InChIKey: SGFPDJDJSONUPO-JAEJYZBISA-N

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 3.39 µM

Function Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Matsui T., Li C.-H., Osajima Y.

Title

Preparation and characterization of novel bioactive peptides responsible for angiotensin I-converting enzyme inhibition from wheat germ. J. Peptide Sci., 5, 289-297, 1999

Year 1999

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC(=O)O)C(=O)N[C@@H]([C@H](CC)C)C(=O)NCC(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)O InChI=1S/C30H39N5O10/c1-3-16(2)26(35-27(41)21(31)14-25(39)40)29(43)32-15-24(38)33-22(12-17-4-8-19(36)9-5-17)28(42)34-23(30(44)45)13-18-6-10-20(37)11-7-18/h4-11,16,21-23,26,36-37H,3,12-15,31H2,1-2H3,(H,32,43)(H,33,38)(H,34,42)(H,35,41)(H,39,40)(H,44,45)/t16-,21-,22-,23-,26-/m0/s1 InChIKey: SGFPDJDJSONUPO-JAEJYZBISA-N

Number_of_Residues

5