TPDB

3D PDB MODEL

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TPDB ID TPDB47897

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 5-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.

Sequence

IRPVQ

FASTA

>TPDB47897|ACE inhibitors;Antihypertensive|length=5
IRPVQ

Formula C27H49N9O7

Absent Amino Acids ANDCEGHLKMFSTWY

Common Amino Acids RQIPV

Mass 611.74

PI 11.05

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 2

Net Charge +1

Boman Index 1.60

Hydrophobicity -0.180

Aliphatic Index 136.00

Half Life

Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

0

A

1

R

0

N

0

D

0

C

0

E

1

Q

0

G

0

H

1

I

0

L

0

K

0

M

0

F

1

P

0

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 1

Length

5

Formula

C27H49N9O7

Mass

611.74

PI

11.05

Net Charge

+1

Boman Index

1.60

Hydrophobicity

-0.180

Chemical_Mass

611.7321

Monoisotopic_Mass

611.3744

Evidence 1 Activity

Activity

Activity Endpoint EC50

Detail Source Activity ACE inhibitors

Activity Measurement 0.00 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Karaki H., Kuwahara M., Sugano S., Doi C., Doi K., Matsumura N., Shimizu T.

Title

Oral administration of peptides derived from bonito bowels decreases blood pressure in spontaneously hypertensive rats. Comp. Biochem. Physiol., 104C, 351-

Year 1993

Literature Source Journal

Other

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](C)(CC)[C@]([H])(N)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCC(N)=O)C(O)=O InChI=1S/C27H49N9O7/c1-5-15(4)20(29)23(39)33-16(8-6-12-32-27(30)31)25(41)36-13-7-9-18(36)22(38)35-21(14(2)3)24(40)34-17(26(42)43)10-11-19(28)37/h14-18,20-21H,5-13,29H2,1-4H3,(H2,28,37)(H,33,39)(H,34,40)(H,35,38)(H,42,43)(H4,30,31,32)/t15-,16-,17-,18-,20-,21-/m0/s1 InChIKey=JAFYOUPRYNYFED-ZKHIMWLXSA-N

Evidence 2 Activity

Activity

Activity Endpoint EC50

Detail Source Activity Antihypertensive

Activity Measurement 0.00 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Karaki H., Kuwahara M., Sugano S., Doi C., Doi K., Matsumura N., Shimizu T.

Title

Oral administration of peptides derived from bonito bowels decreases blood pressure in spontaneously hypertensive rats. Comp. Biochem. Physiol., 104C, 351-

Year 1993

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](C)(CC)[C@]([H])(N)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCC(N)=O)C(O)=O InChI=1S/C27H49N9O7/c1-5-15(4)20(29)23(39)33-16(8-6-12-32-27(30)31)25(41)36-13-7-9-18(36)22(38)35-21(14(2)3)24(40)34-17(26(42)43)10-11-19(28)37/h14-18,20-21H,5-13,29H2,1-4H3,(H2,28,37)(H,33,39)(H,34,40)(H,35,38)(H,42,43)(H4,30,31,32)/t15-,16-,17-,18-,20-,21-/m0/s1 InChIKey=JAFYOUPRYNYFED-ZKHIMWLXSA-N

Number_of_Residues

5