TPDB

3D PDB MODEL

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TPDB ID TPDB47892

Peptide_Name

ACE inhibitor from as2-casein

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

FermFooDB Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 3-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from FermFooDB, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.

Sequence

IPY

FASTA

>TPDB47892|ACE inhibitors;Antihypertensive|length=3
IPY

Formula C20H29N3O5

Absent Amino Acids ARNDCEQGHLKMFSTWV

Common Amino Acids IPY

Mass 391.47

PI 5.94

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 2

Net Charge -0

Boman Index -0.80

Hydrophobicity 0.533

Aliphatic Index 130.00

Half Life

Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 1490

Absorbance 280nm 380.62

Polar Residues 1

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

1

I

0

L

0

K

0

M

0

F

1

P

0

S

0

T

0

W

1

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 0

Length

3

Formula

C20H29N3O5

Mass

391.47

PI

5.94

Net Charge

-0

Boman Index

-0.80

Hydrophobicity

0.533

Chemical_Mass

391.4602

Monoisotopic_Mass

391.2100

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 206.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source FermFooDB

Authors Gómez-Ruiz J. A., Ramos M., Recio I.

Title

Angiotensin-converting enzyme-inhibitory peptides in Manchego cheeses manufactured with different starter cultures. Int. Dairy J., 12, 697-706, 2002

Year 2002

Literature Source Journal

Other

Number of Residues 3

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])([C@]([H])(CC)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)O InChI=1S/C20H29N3O5/c1-3-12(2)17(21)19(26)23-10-4-5-16(23)18(25)22-15(20(27)28)11-13-6-8-14(24)9-7-13/h6-9,12,15-17,24H,3-5,10-11,21H2,1-2H3,(H,22,25)(H,27,28)/t12-,15-,16-,17-/m0/s1 InChIKey=XOZOSAUOGRPCES-STECZYCISA-N Antioxidative peptide according to the EROP-Moscow database Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the EROP-Moscow database

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 206.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB FermFooDB

Authors Gómez-Ruiz J. A., Ramos M., Recio I.

Title

Angiotensin-converting enzyme-inhibitory peptides in Manchego cheeses manufactured with different starter cultures. Int. Dairy J., 12, 697-706, 2002

Year 2002

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 3

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])([C@]([H])(CC)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)O InChI=1S/C20H29N3O5/c1-3-12(2)17(21)19(26)23-10-4-5-16(23)18(25)22-15(20(27)28)11-13-6-8-14(24)9-7-13/h6-9,12,15-17,24H,3-5,10-11,21H2,1-2H3,(H,22,25)(H,27,28)/t12-,15-,16-,17-/m0/s1 InChIKey=XOZOSAUOGRPCES-STECZYCISA-N Antioxidative peptide according to the EROP-Moscow database Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the EROP-Moscow database

Number_of_Residues

3