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Peptide record

TPDB47787

ACE inhibitor MKP ACE inhibitors Antihypertensive Blood-Brain Barrier standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB47787
ACE inhibitor MKP
ACE inhibitors Antihypertensive Blood-Brain Barrier
Cardiometabolic peptides Delivery and barrier-penetrating peptides
Peptipedia AHTPDB
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Blood-Brain Barrier) peptide sequence curated from Peptipedia and AHTPDB, with an available 3D structural model.
Sequence
MKP
Physicochemical Analysis
C16H30N4O4S1
ARNDCEQGHILFSTWYV
KMP
374.50
10.10
1
0
1
+1
1.21
-1.200
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
1
K
1
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 1 M: 1 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
3
C16H30N4O4S1
374.50
10.10
+1
1.21
-1.200
374.4987
Linear
374.1981
Similarity
Met-Lys-Pro
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
0.43 µM
Inhibitor of angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Yamada A., Sakurai T., Ochi D., Mitsuyama E., Yamauchi K., Abe F.
Antihypertensive effect of the bovine casein-derived peptide Met-Lys-Pro. Food Chem.,172, 441-446, 2015
2015
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCSC)C(=O)N[C@@]([H])(CCCCN)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C16H30N4O4S/c1-25-10-7-11(18)14(21)19-12(5-2-3-8-17)15(22)20-9-4-6-13(20)16(23)24/h11-13H,2-10,17-18H2,1H3,(H,19,21)(H,23,24)/t11-,12-,13-/m0/s1 InChIKey=IRVONVRHHJXWTK-AVGNSLFASA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
0.43 µM
Inhibitor of angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Yamada A., Sakurai T., Ochi D., Mitsuyama E., Yamauchi K., Abe F.
Antihypertensive effect of the bovine casein-derived peptide Met-Lys-Pro. Food Chem.,172, 441-446, 2015
2015
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCSC)C(=O)N[C@@]([H])(CCCCN)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C16H30N4O4S/c1-25-10-7-11(18)14(21)19-12(5-2-3-8-17)15(22)20-9-4-6-13(20)16(23)24/h11-13H,2-10,17-18H2,1H3,(H,19,21)(H,23,24)/t11-,12-,13-/m0/s1 InChIKey=IRVONVRHHJXWTK-AVGNSLFASA-N
Evidence 3 Activity

Activity

Blood-Brain Barrier

Assay & Model

Origin/Source
50 μg
Alzheimer’s Disease Assessment Scale
It is casein- derived angiotensin-converting enzyme inhibitory peptide with the potential to cross t

Source & Reference

NA
B3Pdb

Other

Casein
Oral
The safety of daily MKP intake and its potential to improve orientation in adults without dementia.
Additional Detail Fields 2 fields
Oral
3