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Peptide record

TPDB47779

ACE inhibitor ACE inhibitors Antihypertensive standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB47779
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia and AHTPDB, with an available 3D structural model.
Sequence
ARY
Physicochemical Analysis
C18H28N6O5
NDCEQGHILKMFPSTWV
ARY
408.46
9.88
1
0
2
+1
-0.30
-1.333
33.33
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
1490
364.79
1
Residue Composition
number
1
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
3
C18H28N6O5
408.46
9.88
+1
-0.30
-1.333
408.4510
408.2115
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
1.30 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Kumagai Y., Toji K., Katsukura S., Morikawa R., Uji T., Yasui H., Shimizu T., Kishimura H.
Characterization of ACE inhibitory peptides prepared from Pyropia pseudolinearis protein. Marine Drugs, 19, 200, 2021
2021
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)O InChI=1S/C18H28N6O5/c1-10(19)15(26)23-13(3-2-8-22-18(20)21)16(27)24-14(17(28)29)9-11-4-6-12(25)7-5-11/h4-7,10,13-14,25H,2-3,8-9,19H2,1H3,(H,23,26)(H,24,27)(H,28,29)(H4,20,21,22)/t10-,13-,14-/m0/s1 InChIKey: WYPUMLRSQMKIJU-BPNCWPANSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
1.30 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Kumagai Y., Toji K., Katsukura S., Morikawa R., Uji T., Yasui H., Shimizu T., Kishimura H.
Characterization of ACE inhibitory peptides prepared from Pyropia pseudolinearis protein. Marine Drugs, 19, 200, 2021
2021
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)O InChI=1S/C18H28N6O5/c1-10(19)15(26)23-13(3-2-8-22-18(20)21)16(27)24-14(17(28)29)9-11-4-6-12(25)7-5-11/h4-7,10,13-14,25H,2-3,8-9,19H2,1H3,(H,23,26)(H,24,27)(H,28,29)(H4,20,21,22)/t10-,13-,14-/m0/s1 InChIKey: WYPUMLRSQMKIJU-BPNCWPANSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
3