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Peptide record

TPDB47737

ACE inhibitor from myosin heavy chain ACE inhibitors Antihypertensive Neuropeptide standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB47737
ACE inhibitor from myosin heavy chain
ACE inhibitors Antihypertensive Neuropeptide
Cardiometabolic peptides Neuroactive peptides
Peptipedia AHTPDB AHTpin
standard
No
A 5-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Neuropeptide) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
ITTNP
Physicochemical Analysis
C23H40N6O9
ARDCEQGHLKMFSWYV
T
544.61
6.02
0
0
1
-0
0.84
-0.400
78.00
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
3
Residue Composition
number
0
A
0
R
1
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
0
L
0
K
0
M
0
F
1
P
0
S
2
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 2 W: 0 Y: 0 V: 0
Chemical Descriptors
5
C23H40N6O9
544.61
6.02
-0
0.84
-0.400
544.5969
544.2847
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
549.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

NA
Arihara K.,Nakashima Y., Mukai T., Ishikawa S., Itoh M.
Peptide inhibitors for angiotensin I-converting enzyme from enzymatic hydrolysates of porcine skeletal muscle. Meat Sci., 57, 319-324, 2001
2001
Journal

Other

5
Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001 Peptide released from myosin by simulated gastric juice. Terashima M., Baba T., Ikemoto N., Katayama M., Morimoto T., Matsumura S., 2010, Novel angiotensin-converting enzyme (ACE) inhibitory peptides derived from boneless chicken leg meat. J. Agric. Food Chem., 58, 7432-7436
Evidence 2 Activity

Activity

IC50
Antihypertensive
549.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Arihara K.,Nakashima Y., Mukai T., Ishikawa S., Itoh M.
Peptide inhibitors for angiotensin I-converting enzyme from enzymatic hydrolysates of porcine skeletal muscle. Meat Sci., 57, 319-324, 2001
2001
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
5
Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001 Peptide released from myosin by simulated gastric juice. Terashima M., Baba T., Ikemoto N., Katayama M., Morimoto T., Matsumura S., 2010, Novel angiotensin-converting enzyme (ACE) inhibitory peptides derived from boneless chicken leg meat. J. Agric. Food Chem., 58, 7432-7436
Additional Detail Fields 1 fields
5