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Peptide record

TPDB47730

ACE inhibitor ACE inhibitors Antihypertensive standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB47730
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB AHTpin
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
LRW
Physicochemical Analysis
C23H35N7O4
ANDCEQGHIKMFPSTYV
RLW
473.58
11.05
1
0
2
+1
-1.60
-0.533
130.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
5500
1161.38
0
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
0
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
3
C23H35N7O4
473.58
11.05
+1
-1.60
-0.533
473.5671
473.2743
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
0.15 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Wu J., Yuan L., Aluko R.
Restriction of the in vitro formation of angiotensin II by leucinyl-arginyl-tryptophan a novel peptide with potent angiotensin I converting inhibitory activity. Biosci. Biotechnol. Biochem., 70(5) 1277-1280, 2006
2006
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC1=C[N]([H])C2=CC=CC=C12)C(=O)O InChI=1S/C23H35N7O4/c1-13(2)10-16(24)20(31)29-18(8-5-9-27-23(25)26)21(32)30-19(22(33)34)11-14-12-28-17-7-4-3-6-15(14)17/h3-4,6-7,12-13,16,18-19,28H,5,8-11,24H2,1-2H3,(H,29,31)(H,30,32)(H,33,34)(H4,25,26,27)/t16-,18-,19-/m0/s1 InChIKey=XYUBOFCTGPZFSA-WDSOQIARSA-N LRW was found within the primary structure of legumin A2 of a garden pea seeds (Pisum sativum) (position:377-379) and legumin A (position: 374-376). Peptide stimulating activity of osteoblasts according to the BIOPEP-UWM database of bioactive peptides (ID 9878)
Evidence 2 Activity

Activity

IC50
Antihypertensive
0.15 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Wu J., Yuan L., Aluko R.
Restriction of the in vitro formation of angiotensin II by leucinyl-arginyl-tryptophan a novel peptide with potent angiotensin I converting inhibitory activity. Biosci. Biotechnol. Biochem., 70(5) 1277-1280, 2006
2006
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC1=C[N]([H])C2=CC=CC=C12)C(=O)O InChI=1S/C23H35N7O4/c1-13(2)10-16(24)20(31)29-18(8-5-9-27-23(25)26)21(32)30-19(22(33)34)11-14-12-28-17-7-4-3-6-15(14)17/h3-4,6-7,12-13,16,18-19,28H,5,8-11,24H2,1-2H3,(H,29,31)(H,30,32)(H,33,34)(H4,25,26,27)/t16-,18-,19-/m0/s1 InChIKey=XYUBOFCTGPZFSA-WDSOQIARSA-N LRW was found within the primary structure of legumin A2 of a garden pea seeds (Pisum sativum) (position:377-379) and legumin A (position: 374-376). Peptide stimulating activity of osteoblasts according to the BIOPEP-UWM database of bioactive peptides (ID 9878)
Additional Detail Fields 1 fields
3