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Peptide record

TPDB47726

ACE inhibitor Antihypertensive standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB47726
ACE inhibitor
Antihypertensive
Cardiometabolic peptides
AHTPDB AHTpin Peptipedia
standard
No
A 3-aa standard natural antihypertensive peptide sequence curated from AHTPDB, AHTpin, and Peptipedia, with an available 3D structural model.
Sequence
AWW
Physicochemical Analysis
C25H27N5O4
RNDCEQGHILKMFPSTYV
W
461.52
6.02
0
0
3
-0
-3.87
0.000
33.33
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
11000
2383.43
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
3
C25H27N5O4
461.52
6.02
-0
-3.87
0.000
461.5119
461.2057
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
Antihypertensive
9.40 µM
Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Lin Y.-H., Chen C.-A., Tsai J.-S., Chen G.-W.
Preparation and identification of novel antihypertensive peptides from the in vitro gastrointestinal digestion of marine Cobia skin hydrolysates. Nutrients, 11, 1351, 2019
2019
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C)C(=O)N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)O InChI=1S/C25H27N5O4/c1-14(26)23(31)29-21(10-15-12-27-19-8-4-2-6-17(15)19)24(32)30-22(25(33)34)11-16-13-28-20-9-5-3-7-18(16)20/h2-9,12-14,21-22,27-28H,10-11,26H2,1H3,(H,29,31)(H,30,32)(H,33,34)/t14-,21-,22-/m0/s1 InChIKey=CKIBTNMWVMKAHB-RWGOJESNSA-N
Additional Detail Fields 1 fields
3