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Peptide record

TPDB47721

ACE Inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) ACE inhibitors Antihypertensive Neuropeptide iDPPIV standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB47721
ACE Inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
ACE inhibitors Antihypertensive Neuropeptide iDPPIV
Cardiometabolic peptides Neuroactive peptides
FermFooDB Peptipedia AHTPDB AHTpin iDPPIV
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Neuropeptide, and other sources) peptide sequence curated from FermFooDB, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
IQP
Physicochemical Analysis
C16H28N4O5
ARNDCEGHLKMFSTWYV
QIP
356.42
6.02
0
0
1
-0
0.72
-0.200
130.00
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
1
I
0
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
3
C16H28N4O5
356.42
6.02
-0
0.72
-0.200
356.4162
356.2053
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
3.80 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

FermFooDB
Nogata Y., Nagamine T., Yanaka M., Ohta H.
Angiotensin I converting enzyme inhibitory peptides produced by autolysis reactions from wheat bran. J. Agric. Food Chem., 57, 6618-6622, 2009
2009
Journal

Other

3
Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001 Peptide reveals activity in vivo in spontaneously hypertenisve rats: Lu J., Sawano Y., Miyakawa T., Xue Y.-L., Cai M.-Y., Egashira Y., Ren D.-F., Tanokura M., 2011, One-week antihypertensive effect of Ile-Gln-Pro in spontaneously hypertensive rats. J. Agric. Food Chem., 59, 559-563
Evidence 2 Activity

Activity

IC50
Antihypertensive
3.80 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB FermFooDB
Nogata Y., Nagamine T., Yanaka M., Ohta H.
Angiotensin I converting enzyme inhibitory peptides produced by autolysis reactions from wheat bran. J. Agric. Food Chem., 57, 6618-6622, 2009
2009
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001 Peptide reveals activity in vivo in spontaneously hypertenisve rats: Lu J., Sawano Y., Miyakawa T., Xue Y.-L., Cai M.-Y., Egashira Y., Ren D.-F., Tanokura M., 2011, One-week antihypertensive effect of Ile-Gln-Pro in spontaneously hypertensive rats. J. Agric. Food Chem., 59, 559-563
Evidence 3 Activity

Activity

IC50
iDPPIV
0.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Nongonierma A. B., Mooney C., Shields D. C., FitzGerald R. J.
In silico approaches to predict the potential of milk protein-derivedpeptides as dipeptidyl peptidase IV (DPP-IV) inhibitors. Peptides 57, 43-51
2014
Journal

Other

3
Also as ACE inhibitor (BIOPEP ID 8184)
Additional Detail Fields 1 fields
3