TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB47718

Peptide_Name

ACE Inhibitor

Activity

ACE inhibitors Antihypertensive Neuropeptide

Activity_category_statistics

Cardiometabolic peptides Neuroactive peptides

Database_Source

Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 5-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Neuropeptide) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.

Sequence

YYAPF

FASTA

>TPDB47718|ACE inhibitors;Antihypertensive;Neuropeptide|length=5
YYAPF

Formula C35H41N5O8

Absent Amino Acids RNDCEQGHILKMSTWV

Common Amino Acids Y

Mass 659.74

PI 5.88

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 4

Net Charge -0

Boman Index -2.73

Hydrophobicity 0.080

Aliphatic Index 20.00

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 2980

Absorbance 280nm 451.69

Polar Residues 2

number

1

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

0

L

0

K

0

M

1

F

1

P

0

S

0

T

0

W

2

Y

0

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 2 V: 0

Length

5

Formula

C35H41N5O8

Mass

659.74

PI

5.88

Net Charge

-0

Boman Index

-2.73

Hydrophobicity

0.080

Chemical_Mass

659.7271

Monoisotopic_Mass

659.2945

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 24.60 µM

Function Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Takayanagi T., Yokotsuka K.

Title Angiotensin I converting enzyme-inhibitory peptides from wine. Am. J. Enol. Viticult., 50, 65-68, 1999

Year 1999

Literature Source Journal

Other

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N[C@@H](C)C(=O)N3[C@@H](CCC3)C(=O)N[C@@H](CC4=CC=CC=C4)C(=O)O InChI=1S/C35H41N5O8/c1-21(34(46)40-17-5-8-30(40)33(45)39-29(35(47)48)20-22-6-3-2-4-7-22)37-32(44)28(19-24-11-15-26(42)16-12-24)38-31(43)27(36)18-23-9-13-25(41)14-10-23/h2-4,6-7,9-16,21,27-30,41-42H,5,8,17-20,36H2,1H3,(H,37,44)(H,38,43)(H,39,45)(H,47,48)/t21-,27-,28-,29-,30-/m0/s1 InChIKey: HDVQGCCHDCQXPO-WRTIUAHLSA-N

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 24.60 µM

Function Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Takayanagi T., Yokotsuka K.

Title Angiotensin I converting enzyme-inhibitory peptides from wine. Am. J. Enol. Viticult., 50, 65-68, 1999

Year 1999

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N[C@@H](C)C(=O)N3[C@@H](CCC3)C(=O)N[C@@H](CC4=CC=CC=C4)C(=O)O InChI=1S/C35H41N5O8/c1-21(34(46)40-17-5-8-30(40)33(45)39-29(35(47)48)20-22-6-3-2-4-7-22)37-32(44)28(19-24-11-15-26(42)16-12-24)38-31(43)27(36)18-23-9-13-25(41)14-10-23/h2-4,6-7,9-16,21,27-30,41-42H,5,8,17-20,36H2,1H3,(H,37,44)(H,38,43)(H,39,45)(H,47,48)/t21-,27-,28-,29-,30-/m0/s1 InChIKey: HDVQGCCHDCQXPO-WRTIUAHLSA-N

Number_of_Residues

5